Anesthetic and cardiorespiratory effects of total intravenous anesthesia (TIVA) technique using propofol-guaifenesin-medetomidine (PGM) and alfaxalone-guaifenesin-medetomidine (AGM) were preliminarily evaluated in Thoroughbred horses undergoing castration. Twelve male Thoroughbred horses were assigned randomly into two groups. After premedication with intravenous (IV) administrations of medetom...

The aim of this study was to investigate the effects of agmatine (Agm) on the electrical activity of neurons in subfornical organ (SFO) slices using extracellular recording technique. The results are as follows. (1) In response to the application of Agm (1.0 micromol/L) into the superfusate for 2 min, the discharge rate of 24/28 (85.7%) subfornical neurons was decreased significantly, while the...

Learning and adaptation is a fundamental property of intelligent agents. In the context of adaptive information filtering, a filtering agent’s beliefs about a user’s information needs have to be revised regularly with reference to the user’s most current information preferences. This learning and adaptation process is essential for maintaining the agent’s filtering performance. The AGM belief r...

Presently, few treatments for spinal cord injury (SCI) are available and none have facilitated neural regeneration and/or significant functional improvement. Agmatine (Agm), a guanidinium compound formed from decarboxylation of L-arginine by arginine decarboxylase, is a neurotransmitter/neuromodulator and been reported to exert neuroprotective effects in central nervous system injury models inc...

The clarification on the collapse mechanism of a caisson breakwater has been an urgent task in order to reduce damages caused by next millennium tsunamis. In this study, piping destruction of a mound induced by seepage flow is taken into consideration solely. A stabilized ISPH method proposed by Asai (2012) is adopted with some modification associated with the extended Darcy law (Akbari 2013, 2...

The precise time of appearance of the first hematopoietic stem cell activity in the developing mouse embryo is unknown. Recently the aorta-gonad-mesonephros region of the developing mouse embryo has been shown to possess hematopoietic colony-forming activity (CFU-S) in irradiated recipient mice. To determine whether the mouse embryo possesses definitive hematopoietic stem cell activity in the a...

High simian immunodeficiency virus (SIV) seroprevalence rates have been reported in the different African green monkey (AGM) subspecies. Genetic diversity of these viruses far exceeds the diversity observed in the other lentivirus-infected human and nonhuman primates and is thought to reflect ancient introduction of SIV in the AGM population. We investigate here genetic diversity of SIVagm in w...

Nesterov’s accelerated gradient methods (AGM) have been successfully applied in many machine learning areas. However, their empirical performance on training maxmargin models has been inferior to existing specialized solvers. In this paper, we first extend AGM to strongly convex and composite objective functions with Bregman style prox-functions. Our unifying framework covers both the ∞-memory ...

Agomelatine (AGM) was approved for the treatment of major depressive disorder (MDD) in adults by the European Medicines Agency (EMA) in February 2009. It is an analogue of melatonin and features a unique pharmacodynamic profile with agonism on both types of melatonergic receptors (MT1/MT2) and antagonism at serotonergic 5-HT2C receptors. There is, however, an ongoing debate regarding the effica...