Aim: The aim of this study was to verify the pain behavior to electroacupuncture (EACP) in rabbit tooth-pulp assay. Methods: Albino rabbits weighing 1.5-2.0 kg) were pretreated with saline or morphine (5mg/kg, e.v.) 10 min before the nociceptive test (NT). In another group, EACP (rectangular pulses, f1=2 Hz, f2=0.1 s, 3 mA) was applied in acupoints and sham points, before and during the NT. Aft...

OBJECTIVES To evaluate hypoxia-inducible factor 1 subunit α (HIF-1α) expression during the performance of extracorporeal shock wave lithotripsy (ESWL) and to investigate the effects of pentoxyphylline on HIF-1α expression. METHODS One hundred New Zealand Albino rabbit were used in the study divided in 5 groups. There were 20 rabbits in each group. The groups were divided in two parts: early (...

OBJECTIVES To compare the inflammatory reaction associated with the insertion of silicone and polypropylene endplates and endplates made of a new biocompatible polymer, Vivathane, in the rabbit subconjunctival space. METHODS Similar-sized endplates made of 3 different biomaterials were sutured to the sclera in the superotemporal quadrant of the rabbit eye. Thirty eyes of 15 albino New Zealand...

Derivatives of IS!-substituted phenothiazine are concentrated in the tissues of the uveal tract of pigmented animals. The concentration levels for phenothiazine in the uveal tissue may reach 50 times the mean distribution value even 48 hours after a single dose of 5 mg. per kilogram. All other tissues have lower concentration levels than the mean distribution value. Only samples involved in exc...

Keloids and hypertrophic scars are basically an overabundance of fibrosis in cutaneous healing process. Unfortunately, keloids are only found in human beings. So far no successful animal model of keloid has been reported. Objectives: To produce an animal model of keloid. Main Outcome Measure: Animal model of keloid. Design: Prospective quasiexperimental trial. Setting: Department of Pathology a...

The intracellular adenine nucleotide pool of rabbit iris-ciliary body was labelled by uptake of 3H-adenine in vitro. A variety of agents were tested for their ability to stimulate or inhibit the incorporation of radioactivity into cyclic AMP formed from ATP labelled with 3H-adenine. Isoproterenol, vasoactive intestinal peptide, forskolin, and prostaglandin E2 stimulated incorporation of label 3...

PURPOSE A variety of anti-glaucomatous shunt designs have been proposed so far. This study evaluates the feasibility of a novel shunt design, the intra-scleral parathalamus implant (IPI), in a rabbit eye model. METHODS Ten healthy albino rabbits were included. Measurements of the IOP, using TonoPenXL, as well as ocular rigidity (OR) and aqueous outflow facility (AO), using a previously descri...

The mouse model has been used previously for the study of protection against challenge with strains of group B Streptococcus types Ia, Ib, and Ic, but investigators have not yet been successful in causing lethal disease when type III strains are inoculated. In this study, six clinical isolates belonging to serotype III were lethal in seven-week-old outbred albino mice; the 50% lethal dose (LD50...

AIMS To determine whether a new, reversible thermosetting gel enhances mitomycin C transfer to target ocular tissues in the rabbit eye. METHODS A 0.1 ml solution of mitomycin C containing 0.22 microgram, 2.9 micrograms, or 28 micrograms of the agent dissolved in a reversible thermosetting gel consisting of methylcellulose, citric acid, and polyethylene glycol was injected subconjunctivally in...

OBJECTIVE To determine whether intravitreal dexamethasone administration can alter the elimination of intravitreal vancomycin hydrochloride in rabbit eyes with experimental Streptococcus pneumoniae endophthalmitis. METHODS Albino rabbits were infected with an intravitreal inoculum of S pneumoniae (2 x 10(3) colony-forming units) and randomized after 24 hours to treatment with intravitreal van...