Grafting of microencapsulated pancreatic islets has been proposed as an alternative to exogenous insulin for the treatment type 1 diabetes mellitus. Microencapsulated are protected from direct contact with immune cells and larger immune-active molecules such immunoglobulins. Unfortunately, many islet in microcapsules lost immediate period after transplantation due early host response limiting l...

OBJECTIVE Transplantation of insulin-producing cells placed inside microcapsules is being trialled to overcome the need for immunosuppressive therapy. RESEARCH DESIGN AND METHODS Four type 1 diabetic patients with no detectable C-peptide received an intraperitoneal infusion of islets inside microcapsules of barium alginate (mean 178,200 islet equivalents on each of eight occasions). RESULTS...

When administered intravenously, active targeting of drug nanocarriers (NCs) improves biodistribution and endocytosis. Targeting may also improve oral delivery of NCs to treat gastrointestinal (GI) pathologies or for systemic absoption. However, GI instability of targeting moieties compromises this strategy. We explored whether encapsulation of antibody-coated NCs in microcapsules would protect...

      An oral suspension could a suitable dosage form for the geriatric patients. The calcium alginate coated ion exchange resinate of propranolol hydrochloride were prepared using Amberlite IR-120 by solvent evaporation. Microcapsules of propranolol hydrochloride resinate were prepared by solvent evaporation technique,the suspensions were prepared by using deionised water as the vehicle. Methy...

Beta-carotene is the main dietary source of Vitamin A, an essential micronutrient required to maintain proper health. The in vivo bioavailability and absorption of beta-carotene, however, is limited due to the inhibition by the natural plant matrices in which it is found. This study focused on microencapsulation methods to improve release and bioavailability in vitro. Alginate and chitosan form...

To investigate the antiangiogenic potential of encapsulated VEGF₁₆₅b producing HEK293 cells, Human Embryonic Kidney 293 (HEK293) cells were stably transfected to produce VEGF₁₆₅b. Then they were encapsulated in alginate-polylysine-alginate (APA) microcapsules. VEGF₁₆₅b productivity and viability of encapsulated cells were analyzed and compared with the non-encapsulated cells. Results showed tha...

Amoxicillin (α-amino-p-hydroxybenzyl-penicillin) is a semi-synthetic, orally absorbed and widely prescribed β-lactam antibiotic. It is now widely used for eradication of gastric Helicobacter pylori infection combined with a second antibiotic and an acid‐suppressing agent despite its short elimination half-life of one hour. The purpose of this study was to develop and evaluate amoxicillin loaded...

Understanding the mechanical properties of alginate-based microcapsules according to size and chemical composition allows researchers to zero in on the treatment and methods required to engineer optimized implantable alginate-based artificial cells for chemotherapy. Cross-linked medium viscosity alginate capsules ranging from 1.1% (w/v)-1.8% (w/v) in composition and 200 μm-1200 μm in size, enca...

Streptococcus thermophilus is widely used in dairy fermentation as a starter culture for yogurt and cheese production. Many strains are endowed with potential probiotic properties; however, since they might not survive adequate amounts after transit through the human gastrointestinal tract, it advisable to improve cell survivability during this passage. The present study evaluates use of 2′-fuc...