introduction: neuropathic pain syndromes are changes resulting from damage to neuronal pathways that are characterized by spontaneous burning sensation with accompanying allodynia and hyperalgesia. since the treatments of neuropathic pain are poorly understood and existing treatments are often ineffective, it is important to increase our understanding of the neuropathic pain states in order to ...

OBJECTIVE To investigate patients' reported outcome following medication with two brands of 400 mg ibuprofen used to alleviate musculoskeletal pains. METHODS Adult peasant manual laborers (85) who met criteria were randomly assigned to receive either of the brands (A or B). Data on pain alleviation were gathered using the Short-Form McGill Pain Questionnaire (SF-MPQ), Visual Analogue Scale (V...

Restriction alleviation (RA) by the type I restriction enzyme EcoKI is caused by treatments that damage DNA. RA is due to proteolysis of the EcoKI HsdR subunit by the ClpXP ATP-dependent protease. Here we show that the modification-dependent enzyme McrBC is not subject to RA, although it is moderately sensitive to ClpAP.

Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...

background: pain alleviation and its prevention is one of the nursing priorities. morbidity and mortality, time of hospitalization and its cost diminished by adequate pain management .according to the importance of innovative educational method, the current study conducted. methods: this quasi-experimental study conducted on under-teaching nursing students at zabol and zahedan college. 60 stude...

vocational training is one of the crucial elements for generation that is going to be a part of skilled workforce of this world of work and to reduce the level of poverty.  it quickly enables a person to be a part of competitive workforce by enhancing their skills so that he may cope with the rapidly changing technological job and environment. the core objective of this study is to examine the ...

background: subjects with knee osteoarthritis typically have higher knee adduction moment. current research efforts are mainly focused on therapeutic procedures that potentially may modify disease progression. this preliminary study was designed as a single blind (examiner) randomized control trial to investigate the impact of conventional physical therapy on pain, and knee joint load in subjec...