INTRODUCTION High levels of uric acid (UA) have been associated with cardiovascular (CV) disease, but its role as an independent risk factor is the subject of debate. Treating hyperuricemia may be useful in reducing CV risk. OBJECTIVE To review the evidence on the effect of treatment with allopurinol in patients with hyperuricemia on reducing CV events. METHODS We searched medical databases...

BACKGROUND Febuxostat is a novel xanthine oxidase inhibitor. However, few studies have examined the long-term efficacy and tolerability of febuxostat after switching from allopurinol in hemodialysis (HD) patients. Therefore, the present study evaluated the long-term efficacy and tolerability of febuxostat in HD patients after switching from allopurinol. FINDINGS We monitored the levels of hem...

Introduction: High levels of uric acid (UA) have been associated with cardiovascular (CV) disease , but its role as an independent risk factor is the subject of debate. Treating hyperuricemia may be useful in reducing CV risk. Objective: To review the evidence on the effect of treatment with allopurinol in patients with hyperuricemia on reducing CV events. Methods: We searched medical databases...

the effects of allopurinol, acyclovir and theophylline on the activity of adenosine deaminase (ada) were studied in 50 mm sodium phosphate buffer ph 7.5 at 27°c, using a uv– vis spectrophotometer. adenosine deaminase is inhibited by these ligands, via different types of inhibition. allopurinol, as a transition state analog of xanthine oxidase, and acyclovir competitively inhibit the catalytic a...

BACKGROUND AND AIMS We previously reported that IBD patients who are non-responders to thiopurines with preferential shunting of metabolites to hepatotoxic 6-methylmercaptopurine ribonucleotides compared to 6-thioguanine nucleotides can reverse the ratio of 6-MMP/6-TGN and respond to thiopurines with the addition of allopurinol. The objective of this study is to report long term efficacy and sa...

Background: There are 3 main forms of leishmaniasis-visceral, cutaneous, and mucocutaneous. Leishmania parasites are transmitted by the bite of infected female phlebotomine sand flies. Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis and causes skin lesions, leaving life-long scars and serious disability. About 95% of CL cases occur in the Americas, the Mediterranean basin,...

The aim of this study was to observe the effects of uric acid lowering therapy (UALT), febuxostat and allopurinol, on blood pressure (BP) and serum creatinine level. Post-hoc data were derived from a phase-III, randomised, double-blind, 4-week trial of male gouty patients that compared the safety and efficacy of febuxostat and allopurinol in adults with gout. The subjects were randomly assigned...

BACKGROUND Hyperuricemia frequently complicates cyclosporine (CsA) therapy. Previous studies have shown that hyperuricemia exacerbates interstitial and vascular lesions in the cyclosporine model. We tested the hypothesis that normalization of uric acid could prevent the development of cyclosporine toxicity. METHODS CsA nephropathy was induced by administering CsA (15 mg/kg/day) for 7 weeks to...

BACKGROUND Pentavalent antimonials are still the first choice treatment for leishmaniasis, but with low efficacy and resistance is emerging. In the present study, the effect of meglumine antimoniate (MA, Glucantime) combined with paromomycin, miltefosine or allopurinol on in vitro susceptibility of Leishmania tropica resistant isolate was evaluated. METHOD The drugs were obtained from commerc...