Alzheimer disease is characterized by a loss of cholinergic neurons in the basal forebrain and a decrease in acetylcholine levels. Currently, cholinesterase inhibitors, drugs that act by inhibiting the enzyme responsible for the hydrolysis of acetylcholine, are the only therapy for the treatment of Alzheimer disease approved by the Food and Drug Administration. The cholinesterase inhibitors hav...

Microglia are the principal immune cells of the brain. In Alzheimer disease, these brain mononuclear phagocytes are recruited from the blood and accumulate in senile plaques. However, the role of microglia in Alzheimer disease has not been resolved. Microglia may be neuroprotective by phagocytosing amyloid-b (Ab), but their activation and the secretion of neurotoxins may also cause neurodegener...

BACKGROUND In the last decade, many studies have reported abnormal connectivity within the default mode network (DMN) in patients with Alzheimer disease. Few studies, however, have investigated other networks and their association with pathophysiological proteins obtained from cerebrospinal fluid (CSF). METHODS We performed 3 T imaging in patients with mild Alzheimer disease, patients with am...

Alzheimer disease is a devastating neurodegenerative disorder affecting millions of Americans. It reduces the ability of the individual to remain independent, places a burden on caregivers, and substantially increases healthcare costs. New treatments are being tested in numerous clinical trials with the goal of preventing or delaying the onset of Alzheimer disease, slowing or modifying the dise...

BACKGROUND Few studies have investigated the effects of dietary fats on the development of Alzheimer disease. We examined the associations between intake of specific types of fat and incident Alzheimer disease in a biracial community study. METHODS We performed clinical evaluations on a stratified random sample of 815 community residents aged 65 years and older who were unaffected by Alzheime...

PURPOSE To compare brain tissue in patients with Alzheimer disease with that in elderly control subjects by using high-resolution MR imaging and quantitative tissue-segmentation techniques. METHODS MR imaging of the brain was performed in 21 patients with Alzheimer disease and 17 control subjects. A computerized segmentation program was used to quantify volumes of ventricular and sulcal cereb...

In Alzheimer disease, increased b-secretase (BACE1) activity has been associated with neurodegeneration and accumulation of amyloid precursor protein (APP) products. Thus, inactivation of BACE1 could be important in the treatment of Alzheimer disease. In this study, we found that lowering BACE1 levels using lentiviral vectors expressing siRNAs targeting BACE1 reduced amyloid production and the ...

Zhi Cheng Educational school, Guangzhou University, Guangzhou 510006 Abstract: In this paper, we provide another angle to analyze the reasons why Alzheimer Disease exists. We analyze the dynamic mechanism of Alzheimer Disease based on the cognitive model that established from artificial neural network. We can provide some theoretic explanations to Alzheimer Disease through the analyzing of this...

BACKGROUND AND PURPOSE Manually drawn VOI-based analysis shows a decrease in magnetization transfer ratio in the hippocampus of patients with Alzheimer disease. We investigated with whole-brain voxelwise analysis the regional changes of the magnetization transfer ratio in patients with mild Alzheimer disease and patients with amnestic mild cognitive impairment. MATERIALS AND METHODS Twenty pa...