Amebiasis is a relatively common disease in the tropical region of the world especially in the Indian subcontinent. Extra-intestinal dissemination happens through the portal route and hence the liver is the most common site for the same. Other sites can be also involved albeit less commonly. Pericardial involvement is mostly due to extension of the infection of the left lobe of liver due to ana...

Amebiasis is typically an infection of the colon by the protozoan, Endamoeba histolytica. It may be acute or chronic and presents a varied clinical course. The most frequent symptom is diarrhea with small amounts of blood-streaked mucus, but stubborn constipation is not unusual. Often, constipation may alternate with diarrhea accompanied by tenesmus, lassitude, and a generalized vague abdominal...

Protozoan parasites are among the most devastating infectious agents of humans responsible for a variety of diseases including amebiasis, which is one of the three most common causes of death from parasitic disease. The agent of amebiasis is the amoeba parasite Entamoeba histolytica that exists under two stages: the infective cyst found in food or water and the invasive trophozoite living in th...

Amebiasis is a parasitic disease that extends worldwide and is a public health problem in developing countries. Metronidazole is the drug recommended in the treatment of amebiasis, but its contralateral effects and lack of continuity of treatment induce low efficiency, coupled with the appearance of resistant amoebic strains. Therefore, the search of new compounds with amoebicidal activity is u...

Entamoeba histolytica is an invasive intestinal pathogenic parasitic protozoan that causes amebiasis. It must be distinguished from Entamoeba dispar and E. moshkovskii, nonpathogenic commensal parasites of the human gut lumen that are morphologically identical to E. histolytica. Detection of specific E. histolytica antigens in stools is a fast, sensitive technique that should be considered as t...

Human infection with the protozoan intestinal parasite Entamoeba histolytica, which causes amebiasis, usually begins with ingestion of the dormant form of the organism, the cyst, which is present in water or vegetables polluted with human fecal material (54). Studies of the life cycle of this parasite have shown that motile trophozoites emerge after digestion of the tough cyst wall (excystation...

The Gal/GalNAc lectin is a candidate vaccine antigen for an amebiasis vaccine due to its mediation of parasite adherence to the human intestine, because partial immunity in humans is associated with a mucosal IgA response against it, and because it is effective as a vaccine against amebic colitis in the murine model. The LecA domain of the Gal/GalNAc lectin contains neutralizing antibody epitop...