The receptors of amine subfamily are specifically major drug targets for therapy of nervous disorders and psychiatric diseases. The recognition of novel amine type of receptors and their cognate ligands is of paramount interest for pharmaceutical companies. In the past, Chou and co-workers have shown that different types of amine receptors are correlated with their amino acid composition and ar...

PURPOSE Lysyl oxidase-like 1 (LOXL1) is a copper-dependant amine oxidase that plays an essential role in elastogenesis. Two non-synonymous single-nucleotide polymorphisms of LOXL1, R141L (rs1048661) and G153D (rs3825942), have been reported to significantly increase susceptibility to exfoliation glaucoma (XFG). To evaluate the impact of the R141L and G153D variations on the amine oxidase activi...

Nuclear magnetic resonance techniques were used to study the kinetics and products of the reaction of a variety of epoxides with various amines under varying pH conditions. In agreement with a previous finding, the amine-epoxide reactions were found to be water-catalyzed and not directly dependent on the pH of the reaction environment. At pH values higher than the pK(a) of the particular amine,...

concomitant coronary artery bypass surgery (cabg) in patients undergoing mitral valve replacement (mvr) has been shown to be an important risk factor for hospital mortality. we evaluated preoperative characteristics, postoperative complications, in-hospital mortality rate, and length of stay in hospital for patients undergoing concurrent cabg with mvr. preoperative and postoperative clinical da...

Multifunctional enzymes have alternative functions or activities, known as “moonlighting” or “promiscuous”, which are often hidden behind a native enzyme activity and therefore only visible under special environmental conditions. In this thesis, the active-site of Pseudozyma (formerly Candida) antarctica lipase B was explored for a promiscuous conjugate addition activity. Pseudozyma antarctica ...

Triplex forming oligonucleotides (TFOs) are the most commonly used approach for site-specific targeting of double stranded DNA (dsDNA). Important parameters describing triplex formation include equilibrium binding constants (K(eq)) and association/dissociation rate constants (k(on) and k(off)). The 'fluorescent intercalator displacement replacement' (FIDR) assay is introduced herein as an opera...

Cell DNA Gel (all +40U/mL DNase) Media Culture Time CPA Progression Fig 1I A-amine MCF-10A Aprime-lipid n/a n/a n/a 1) 10A&Aprime A-lipid 2) 10A&A 3) 10A&Aprime Fig 2A-C, 3A, S2D-E A-amine MCF-10A Aprime-lipid 9 mg/mL Matrigel 10A Assay Medium 24 hours 1) 10A&Dprime B-amine MCF-10A Bprime-lipid 2) 10A&Bprime D-amine MCF-10A Dprime-lipid 3) 10A&Aprime Fig 2D-H, S2C A-amine MCF-10A Aprime-lipid 9...

We report a chemiresistive sensor approach based on a TTF-TCNQ charge transfer material, which can real-time detect and distinguish the vapors of alkyl amine and aromatic amine species under ambient conditions, based on the dramatic difference in the kinetics of the electric current recovery processes after the exposure of the two amine species.

In this paper, the applicability of immobilized lanthanum (III) triflate on amine grafted graphene oxide [La(OTf)2-amine grafted-GO] as the first multifunctional catalyst is described for the efficient synthesis of α-aminophosphonates by one-pot three-component reaction of carbonyl compounds, substituted anilines and trialkyl phosphites. Various α-aminophosphonates were synthesized in good to h...

The reaction of a Cp*Ir(iii) phosphoramidate complex with secondary amines gives amine, imine-bound Cp*Ir(iii) hydride complexes resulting from amine dehydrogenation. These well-characterized species could serve as models of relevant intermediates that have been proposed in catalytic amine dehydrogenation using related N,O-chelated Cp*Ir(iii) pyridonate complexes.