the effect of chronic inflammation induced by complete freund's adjuvant (cfa) on anterior blood vessels of knee joint and its diameter was studied. blood flow changes in response to phenylephrine (αl-adrenoceptor agonist) in cfa-treated and contralateral knee joints were observed over a 40-day period, using laser doppler flowmetery (ldf) technique. unilateral injection of cfa (0.2 ml) inc...

Guanidine compounds have important biochemical properties. Aminoguanidine, as an example, is an anti-oxidant, a nitric oxide synthase inhibitor (NOS) which prevents nitric oxide formation, and an inhibitor of advanced glycosylation end products (AGEs). As an anti-oxidant, aminoguanidine may affect the formation of atherosclerotic lesions through protection from LDL oxidation. Inhibition of AGEs...

BACKGROUND AND PURPOSE In brain, several cell types produce tumor necrosis factor-alpha (TNFalpha) after injury or exposure to endotoxin. TNFalpha alone or in combination with endotoxin or other cytokines can cause expression of inducible nitric oxide (NO) synthase. We have previously demonstrated that endotoxin caused NO-dependent dilatation of cerebral arterioles in vivo. In the present study...

BACKGROUND beta-adrenergic hyporesponsiveness in many cardiomyopathies is linked to expression of inducible nitric oxide synthase (iNOS) and increased production of NO. The purpose of this study was to examine whether iNOS expression alters the function of the sarcoplasmic reticulum (SR) Ca(2+) release channel (ryanodine receptor, RyR) during beta-adrenergic stimulation. METHODS AND RESULTS E...