Molecular complexes have been prepared from several biologically active methoxyamphetamines and 1,4-dinitrobenzene. The association constants of these complexes, determined by nuclear magnetic resonance measurements, correlate linearly with the threshold hallucinogenic dose in humans.

The aim of this article was to describe the attention functioning of twenty-two truck drivers and its relationship with amphetamine use. Those drivers who reported using amphetamines in the twelve months previous to the interview had the best performance in a test evaluating sustained attention functioning. Although amphetamine use may initially seem advantageous to the drivers, it may actually...

This category of drugs principally includes amphetamine, methamphetamine and amphetamine-like drugs such as phenmetrazine and methyphenidate. Those who use these drugs non-medically tend to fall into three categories. First, those who use these drugs orally, on a rather regular basis, in small to moderate doses, without prescription or as a result of 'prescription shopping', and usually to elev...

This article discusses the misuse of drugs which act as stimulants, an effect mainly produced by enhancement of the central transmission of catecholamines, particularly dopamine. Stimulant misuse is extremely widespread in the UK and elsewhere, but primary users of such drugs present relatively rarely for treatment at drug services. At present such services mainly see heroin users, not only bec...

A 62-year-old Caucasian woman underwent evaluation for possible liver transplantation. She had endstage cirrhosis secondary to hepatitis C and alcohol abuse. Among the tests ordered were urine screens for various drugs of abuse, including amphetamines, for which the patient’s urine sample was positive. Given the patient’s history of alcohol abuse and possible other drug abuse, her physicians qu...

INTRODUCTION A number of neuropsychological studies have shown the relationship between severity of drug abuse and the executive functioning of substance abusers, along with its negative impact on treatment results. AIM The aim of this study is to examine the relationship between severity of consumption of alcohol, cannabis, cocaine, heroin, amphetamines and ecstasy on the executive processes...

PURPOSE The purpose of this study was to determine the relationship between amphetamine ingestion and gingival enlargement. METHODS A total of 40 subjects were included in this study. Group 1 consisted of 20 subjects taking amphetamines and attending the dental clinic at Children's Hospital of Buffalo and The University at Buffalo School of Dental Medicine. These subjects were not taking phen...

A small set of amphetamines has been analyzed by gas chromatography (GC) high-resolution time-of-flight mass spectrometry (TOFMS) using a microplasma photoionization (MPPI) soft-ionization source. This plasma-based, wavelength selectable ionization source enables ionization of the test compounds and their corresponding derivatives at ~8-12 eV that is a softer alternative to electron ionization ...

We describe a simple HPLC method which is suitable for the routine confirmation of immunoassay positive amphetamine urine samples. The precolumn derivisation method employing sodium naphthaquinone-4-sulphonate was found to have adequate sensitivity, selectivity and precision for the measurement of amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetam...

In this study, human embryonic kidney (HEK)-293 cells stably expressing human, Drosophila, or a chimeric serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT, dSERT, and H(1-281)D(282-476)H(477-638), respectively) were used to explore the ability of two libraries of structurally distinct psychostimulants to inhibit 5-HT uptake. One library consisted of 3-phenyltropane analogs, whereas the s...