We examined neuroadaptive changes in GABA(B) receptor binding following reinstatement of cocaine-seeking behavior in rat brain structures using a "yoked" procedure and quantitative autoradiographic analysis. To estimate the distribution of GABA(B) receptors in several brain areas, we used [(3)H]CGP 54626, a GABA(B) receptor antagonist. The binding of [(3)H]CGP 54626 in the nucleus accumbens and...

A calcium (Ca2+)-activated potassium (K+) conductance was studied in large pyramidal-like neurons acutely dissociated from the rat basolateral amygdaloid complex. Neurons were immunoreactive to anti-alpha(913-926), a sequence-directed antibody directed against the pore-forming alpha-subunit of the BK(Ca) channel, also termed slo. Whole cell current-voltage (I-V) relationships obtained on applic...

Adult rhesus monkeys with neonatal aspiration lesions of the hippocampal formation or the amygdaloid complex (including their respective subjacent cortices) and their age-matched controls were tested on the transverse patterning problem (A+ vs. B-, B+ vs. C- and C+ vs. A-) and a spatial version of the delayed nonmatching-to-sample (DNMS) task with delays of 10 s to 30 s, 60 s, 120 s, and 600 s....

The amygdaloid complex is a prominent temporal lobe region that is associated with "emotional" information processing. Studies in the rodent have also recently implicated the amygdala in the processing and modulation of pain sensation, the experience of which involves a considerable emotional component in humans. In the present study, we sought to establish the relevance of the amygdala to pain...

The thalamo-amygdaloid connections arising in the posterior thalamus were studied in the brains of rats by the Nauta-Gygax and Fink-Heimer methods. They begin mainly in the neurons of the supero-medial area of the posterior segment of the pulvinar and in the peripeduncular nucleus. The amygdalopetal fibers of this pathway pass through the zona incerta, cerebral peduncle, and the lateral hypotha...

Objectives: Temporal lobe epilepsy (TLE) is the most common seizure type in adults. Recent studies showed that 28–58% of TLE patients had a previous history complex febrile convulsions (CFC). We compared hippocampal volumes and amygdaloid body widths fornix mammillary bodies on magnetic resonance imaging (MRI) with without CFC. Methods: MRI scans 42 subjects retrospectively examined. The amount...

Horseradish peroxidase (HRP) was injected to various parts of the amygdala in 50 rats. Retrograde axonal transport revealed that tegmental areas containing biogenic amines: dorsal and median raphe nuclei, locus coeruleus and ventral tegmental area, project diffusely to various amygdaloid areas. Moreover, HRP labeled cells were found in the parabrachial nucleus (following injection of the latera...