Proteotoxic stresses and aging cause breakdown of cellular protein homeostasis, allowing misfolded proteins to form aggregates, which dedicated molecular machines have evolved to solubilize. In bacteria, fungi, protozoa and plants protein disaggregation involves an Hsp70•J-protein chaperone system, which loads and activates a powerful AAA+ ATPase (Hsp100) disaggregase onto protein aggregate sub...

Hsp70 participates in a broad spectrum of protein folding processes extending from nascent chain folding to protein disaggregation. This versatility in function is achieved through a diverse family of J-protein cochaperones that select substrates for Hsp70. Substrate selection is further tuned by transient complexation between different classes of J-proteins, which expands the range of protein ...

In this paper we develop a dynamic data-consistent way for estimating agricultural land use choices at a disaggregate level (district-level), using more aggregate data (regional-level). The disaggregation procedure requires two steps. The first step consists in specifying and estimating a dynamic model of land use at the regionallevel. In the second step, we disaggregate outcomes of the aggrega...

Disaggregation of resources in the data center, especially at the rack-scale, offers the opportunity to use valuable resources more efficiently. It is common that mass storage racks in large-scale clouds are filled with servers with Hard Disk Drives (HDDs) attached directly to each of them, either using SATA or SAS depending on the number of HDDs. What does disaggregated storage mean for these ...

Smart electricity meters record the aggregate consumption of an entire building. However, appliance-level information is more useful than aggregate data for a variety of purposes including energy management and load forecasting. Disaggregation aims to decompose an aggregate signal into appliance-by-appliance information. Existing disaggregation systems tend to perform well for single-state appl...

Basins generated by a noninvertible mapping formed by two symmetrically coupled logistic maps are studied when the only parameter λ of the system is modified. Complex patterns on the plane are visualized as a consequence of the basins’ bifurcations. According to the already established nomenclature in the literature, we present the relevant phenomenology organized in different scenarios: fracta...

The aggregation and disaggregation behaviors of red blood cells were investigated in 17 normotensive and 21 hypertensive subjects with a laser reflectometry technique, and simultaneous measurements were taken of blood viscosity with a coaxial viscometer. Increased red blood cell aggregation (26%, p less than 0.001) and disaggregation shear rate (20%, p less than 0.01) and shear stress (18%, p l...

The increasing demands on drinkable water, along with population growth, water-intensive agriculture and economic development, pose critical challenges to water sustainability. New techniques to long-term water conservation that incorporate principles of sustainability are expected. Recent studies have shown that providing customers with usage information of fixtures could help them save a cons...

We first review some of the suggested methods for energy disaggregation. We then provide a real-life data set for researchers to help developing novel energy disaggregation algorithms. We also present a publicly available experimental data set captured from a typical building on the University of California, Berkeley campus.