We read with great interest the Highlight Review by Dr C GruÈ ndker entitled `Cytotoxic luteinizing hormonereleasing hormone conjugates and their use in gynecological cancer therapy' in the European Journal of Endocrinology (1). This excellent article provides a detailed description of recent developments in the field of targeted chemotherapy based on luteinizing hormone-releasing hormone (LH-R...

Abstract In this paper the robustness of Brass's child-survivorship indirect mortality estimation technique is investigated. An analytical method is developed for studying the error or bias caused in indirect mortality estimates by poor data, badly chosen model functions, and specific demographic assumptions that are often violated in practice. The resulting analytical expressions give insigh...

or indirect ophthalmoscope, is an optical instrument worn on the examiner’s head, and sometimes attached to spectacles, that is used to inspect the fundus or back of the eye. It produces an stereoscopic image with between 2x and 5x magnification. It is valuable for diagnosis and treatment of retinal tears, holes, and detachments. The pupils must be fully dilated for it to work well. In a dark r...

In this paper we provide insight into the empirical properties of indirect crossvalidation (ICV), a new method of bandwidth selection for kernel density estimators. First, we describe the method and report on the theoretical results used to develop a practical-purpose model for certain ICV parameters. Next, we provide a detailed description of a numerical study which shows that the ICV method u...

On an otherwise symmetric oligopoly market with stochastic demands for heterogeneous products firms can either hire an employee or partner or buy the required labor input on the labor market. Whereas the wage of hired labor does not depend on the realization of stochastic demand, the price of bought labor input reacts positively to product demand. We first solve the market by deriving the equil...