Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used antipyretic agents that most probably exert their antifever effect by inhibiting cyclooxygenase (COX)-2. Thus, COX-2-selective drugs or null mutation of the COX-2 gene reduce or prevent fever. Acetaminophen is antipyretic and analgesic, as are NSAIDs, but it lacks the anti-inflammatory and anticoagulatory properties of these drug...

The aqueous methanolic extract of stem part of Berberis calliobotiys (AMEBC) was evaluated for anti-inflammatory, analgesic and antipyretic activities in albino mice. Anti-inflammatory activity was evaluated by using carrageenan and albumin induced paw edema, while the analgesic effect was assessed by using formalin-induced paw licking and acetic acid induced abdominal writhing in mice. The bre...

Medicinal plants are effective natural anti-inflammatory, anti-pyretic, and anti-analgesic agents. Inflammation is a complicated biological defense reaction of vascular tissues to potentially damaging stimuli such as bacteria, damaged cells, or irritants. The current study aimed establish the antipyretic, analgesic properties E. globulus essential oil. In this research, 36 albino rats weighing ...

Analgesic, anti-inflammatory and anti-pyretic activities of n-hexane aqueous ethanolic extracts Malva neglecta in Swiss albino mice was evaluated. For each activity, the were divided into 4 groups: Group 1 served as control, Groups 2 3 given ethanol extracts, respectively whereas treated with standard drug. Analgesic activity evaluated against acetic acid induced writhing, Eddy's hot plate meth...

Aspirin, indomethacin, and sodium salicylate are anti-inflammatory, analgesic, and antipyretic. Whereas aspirin and indomethacin inhibit prostaglandin synthetase (cyclo-oxygenase; 8,11,14-eicosatrienoate, hydrogen-donor: oxygen oxidoreductase, EC 1.14.99.1), salicylate does not. However, all three drugs affect the metabolism of arachidonate via the lipoxygenase pathway by inhibiting the convers...

The essential oil of Artemisia caerulescens subsp. gallica was observed to have analgesic, antipyretic and anti-inflammatory actions when administered intraperitoneally to rats and mice at doses one-fourth to one-third that of its LD50 of 1.35 ml/kg. Lysine acetylsalicylate was used as a reference compound.

INTRODUCTION Pain is a cardinal feature of inflammation and is responsible for majority of hospital visits. The non-opioid analgesics possess antipyretic and anti-inflammatory activity and thus are often employed for such purpose of controlling inflammation as well as antipyretic. The non-opioid analgesics are freely available devoid of causing dependence but their potential harmful effects can...

Paracetamol is a common analgesic and antipyretic drug for management of fever and mild-to-moderate pain in infants and children, and it is considered as first-line therapy for the treatment of both according to international guidelines and recommendations. The mechanism of action of paracetamol is complex and multifactorial, and several aspects of the pharmacology impact its clinical use, espe...