When a new D-dimer method is evaluated it is typically compared to an established D-dimer method. Usually both an analytical and a clinical comparison are made. The range of clinical specificities between D-dimer assays is wide (from 30 % to above 90 %), which is due to heterogeneity between D-dimer molecules and difference between antibody specificity towards them, especially concerning the pr...

The development of rapid, automated, and accurate laboratory testing for creatine kinase MB (CK-MB) revolutionized the treatment of patients with acute cardiac events in the 1970s and 1980s.1 To clinicians, CK-MB values augmented a thorough history, physical, and ECG findings, and elevations rapidly became the gold standard for identifying cardiac injury.1 CK-MB allowed earlier diagnosis of acu...

This report describes the demonstration and evaluation of an immunoassay field screening technology designed to determine polychlorinated biphenyl (PCB) contamination in soil. The immunoassay technology was the EnviroGard PCB Test developed by Millipore, Inc. The technology was demonstrated in Kansas City, Missouri, in August 1992, by PRC Environmental Management, Inc. (PRC), under contract to ...

Polymerase chain reaction (PCR)-based testing is being widely implemented for diagnostic purposes. The PCR technique is generally considered to be both analytically sensitive (i.e., detects small quantities of a substance) and analytically specific (i.e., few cross reactions). There are few studies, however, of diagnostic sensitivity and specificity (i.e., the likelihood of correctly identifyin...

A number of analytical applications require the probing of turbid media with high chemical specificity. The primary target is the composition of the sample; information that is vital in, for example, the analysis of pharmaceutical tablets to identify the presence of undesired polymorphs. Ideally, information should be obtained non-destructively, noninvasively and rapidly. Practical applications...

emergency physicians, like other specialists, are faced with different patients and various situations each day. they have to use ancillary diagnostic tools like laboratory tests and imaging studies to be able to manage them. in most cases, numerous tests are available. tests with the least error and the most accuracy are more desirable. the power of a test to separate patients from healthy one...

ôbjective: the mood disorder questionnaire (mdq) has been designed as a screening self-report inventory for diagnosing bipolar mood disorders. this study investigated the validity and the optimal cut-off threshold of the persian version of mdq in a group of ïranian depressive patients. methods: ône hundred and twenty patients with probable diagnosis of mood disorders attending psychiatric clini...

abstract background the aim of this study was to evaluate sensitivity and specificity of mediastinal sonography, and compared with ct, in detection of anterior mediastinal neoplasms. materials and methods the sonography with convex probes (5.0 and 7.5 mhz) was done prospectively for 34 patients (from 2 to 25 years old) with mediastinal mass. the results were compared with the results of contras...

With our analytical tools we have analyzed microarray data with over 20,000 genes. We have discovered molecular patterns characteristic of zonal and histological tissue classification of the prostate. We have found promising prostate cancer biomarkers yielding 90% sensitivity and specificity on completely independently collected data. We have also found promising diagnostic markers and new drug...