Polyhalogenated carbazoles (PHCZs) are persistent chemical pollutants increasingly detected in different environmental matrices. They structurally and chemically similar to other organic (POPs), which capable of disrupting the endocrine systems. However, PHCZs such as 3-chloro-9H-carbazole (3-CCZ), 3-bromo-9H-carbazole (3-BCZ), 36-dibromo-9H-carbazole (36-BCZ) rarely discussed context their adv...

Background: Prostate cancer is a disease that occurs in men aged more than 50 years. In Iraq, 8.89 per 100,000 population suffer from prostate cancer, with the incidence being 14,016 cases and mortality 6,367 cases. Despite advances treatment against it can become resistant to drugs. Therefore, aim of current study was search identify binding sites for repositioning ...

The red-spotted garter snake exhibits adult size dimorphism in which females are the larger sex. To understand which hormones may influence differential growth in this species, growth curves and hormone profiles of estradiol-17beta (E2) and testosterone (T) were constructed in male and female neonates. Growth was manipulated via implantation of exogenous hormones and hormone antagonists. Female...

Surgical castration synergizes with immunotherapy, but chemical castration has suppressive effects.

Computational tools, such as quantitative structure-activity relationship (QSAR), are highly useful as screening support for prioritization of substances of very high concern (SVHC). From the practical point of view, QSAR models should be effective to pick out more active rather than inactive compounds, expressed as sensitivity in classification works. This research investigates the classificat...

The antiproliferative effects of an antagonist of growth hormone-releasing hormone (GHRH) JV-1-38 were evaluated in nude mice bearing s.c. xenografts of LNCaP and MDA-PCa-2b human androgen-sensitive and DU-145 androgen-independent prostate cancers. In the androgen-sensitive models, JV-1-38 greatly potentiated the antitumor effect of androgen deprivation induced by surgical castration, but was i...

Gonadal androgen suppression (castration via orchiectomy or gonadotropin-releasing hormone analogues) suppresses circulating testosterone levels but does not achieve adequate androgen ablation within the prostate cancer microenvironment because it does not address adrenal and intratumoral steroid contributions. These residual extragonadal sources of androgens allow prostate cancer cells to surv...