Angiotensin converting enzyme (ACE) inhibitors have been available for the treatment of hypertension and heart failure for several years. This class of drugs is generally well accepted by the patient (1), but an unusual, infrequent, and troublesome side-effect, cough, has become apparent. This article reviews this side-effect and also the possibility of other respiratory effects of ACE inhibition.

The renin-angiotensin-aldosterone system plays a major role in the pathophysiology of hypertension and closely related cardio- and cerebrovascular events. Although both angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor antagonists (angiotensin receptor blockers; ARBs) are equally important in the treatment of hypertension, according to the results of recent years, there mi...

Sir, Angiotensin-converting enzyme (ACE) inhibitors are the most frequently prescribed antihypertensive drugs. Their effects on both hypertension and heart failure are highly beneficial. However, one has to be aware of the potential side effects, approximately 50% occurring in the skin. While angioedema is a well-known adverse cutaneous reaction to ACE inhibitors, other skin reactions are uncom...

Seventeen patients using angiotensin-converting enzyme (ACE) inhibitors for hypertension were evaluated with baseline spirometry followed by determination of bronchial reactivity by challenge with methacholine. There were nine coughers and eight noncoughers in the study. Among the nine coughers, eight demonstrated bronchial hyperreactivity. Conversely, none of the noncoughers disclosed bronchia...

Diabetic nephropathy is the main cause of end stage renal disease both in the USA and in Europe. In addition, the development of diabetic nephropathy greatly increases the cardiovascular risk in these patients. Studies performed with angiotensin converting enzyme (ACE) inhibitors have shown that blockade of the actions of angiotensin II (AII) is the treatment of choice for diabetic patients who...

OBJECTIVE To determine whether inhibition of angiotensin converting enzyme (ACE) can prevent angiotensin II production in the coronary circulation induced by percutaneous transluminal coronary angioplasty (PTCA) in patients with myocardial ischaemia. DESIGN, PATIENTS 41 patients who underwent elective PTCA and six control subjects who received diagnostic coronary angiography were studied. Pat...

background: angiotensin converting enzyme (ace) upregulation in stromal cells of joints affected by rheumatoid arthritis may lead to higher tissue angiotensin ii that is a vasoconstrictor and mitogen factor. to date, the role of angiotensin ii on regulating blood flow in inflamed joints has not been studied.   methods: acute and chronic joint inflammation was induced in rabbits by intra-articul...

The success of Angiotensin-converting enzyme (ACE) inhibitors in preventing the progression of chronic renal insufficiency has led investigators to study the effects of other inhibitors of the renin-angiotensin system (RAS). Recently, the results of the first large-scale trials with angiotensin II type 1 receptor (AT1) antagonists became available (1,2). This article discusses the relative meri...

Two procedures are described for the detection of inhibitors of angiotensin converting enzyme (ACE). The first is a new agar-plate method useful as a screening tool. Two ACE inhibitors produced by culture A58365 were discovered using this plate test. The second method is a modification of a previously reported spectrophotometric procedure. Both procedures utilize p-nitrobenzyl-oxycarbonylglycyl...