C. elegans is sensitive to the majority of anthelmintic drugs that are used against parasitic worm infections of humans and livestock. This has provided the opportunity to use molecular genetic techniques in the worm for mode of action studies. These approaches continue to be of considerable value to the field of parasitology. In addition, there are numerous examples of anthelmintic drugs provi...

BACKGROUND Gastrointestinal parasites are one of the main restrictions to small ruminant production. Their pathological importance is primarily related to the major production losses, in quantity or quality, induced by the direct action of worms. Control of these parasites is based exclusively on the frequent use of anthelmintic drugs. However, the resistance to anthelmintics in worm population...

The present study was aimed to evaluate anthelmintic activity of aqueous and methanolic extract of Trapa natans L.var. bispinosa Roxb fruit peels and root. The plant commonly known as “Water Chestnut” in India and is an annual aquatic floating herb occurring throughout the Indian subcontinent and used traditionally for several medicinal purposes. The effect of this plant was evaluated for anthe...

Knowledge of how anthelmintics are metabolized and excreted in nematodes is an integral part of understanding the factors that determine their potency, spectrum of activity and for investigating mechanisms of resistance. Although there is remarkably little information on these processes in nematodes, it is often suggested that they are of minimal importance for the major anthelmintic drugs. Con...

The objective of this study was to investigate the anthelmintic efficacy of herbal drug (Ocimum sanctum) in Syphacia muris infected mice. The drugs were administrated to the infected mice on 18 , th 19 and 20 post infection days. The % efficacy due to test drug was observed on larva and adult worm th th recovery response. Larval and Adult worm recovery were found to be directly proportional to ...

This survey was conducted in the southern Brazilian state of Rio Grande do Sul and involved 182 farms located in 26 counties. In addition to the three major broad-spectrum anthelmintic groups (viz. benzimidazole, levamisole and ivermectin) the combination benzimidazole and levamisole and the H. contortus specific anthelmintic, closantel, were tested by the faecal egg count reduction method for ...

Malnutrition, anaemia, and gut parasites are commonly interrelated. Using the Nippostrongylus brasiliensis-rat model, the effect of iron and protein deficiency on the efficacy of benzimidazole anthelmintics was studied. It was demonstrated that the anthelmintics mebendazole and fenbendazole were significantly less effective in eradicating parasites when animals were deficient in iron and protei...

Caesalpinia sappan L. is a popular medicinal plant known to both the Ayurveda and Chinese traditional medicines since ancient time. The aim of this research was to study the qualitative phytochemistry and to determine the antioxidant and anthelmintic activities of C. sappan leaves. Phytochemical analysis indicated the presence of various plant bioactive metabolites in C. sappan leaves. Differen...

The crude alcoholic extract of the stem bark of Acacia oxyphylla, an indigenous anthelmintic plant among the Mizo tribes of north-east India, have been demonstrated to exhibit profound anthelmintic effects on the avian gastrointestinal cestode, Raillietina echinobothrida. To further investigate the efficacy of the plant extract with a view to understanding the mode of action, vital trace elemen...

This study was conducted to evaluate the in vitro polyphenol content, antioxidant, cytotoxic, antibacterial, anthelmintic properties, and in vivo antinociceptive activity of the ethanol extract of Cissus adnata leaves (EECA) in different experimental models. Polyphenol contents were investigated using spectrophotometric techniques. Antioxidant activity was determined by 1,1-diphenyl-2-picrylhyd...