The present study aimed to investigate the anti-inflammatory effects of Baicalein on human osteoarthritic chondrocytes and its molecular mechanisms, explore related events that may occur. extracted were stimulated with interleukins. After administered different concentrations Baicalein, survival rate was observed. Apoptosis detected by apoptosis assay kit. effect NO production using Griess reag...

biodegradable polymeric nanoparticles (nps) have been intensively studied as a possible way to enhance anti-tumor efficacy while reducing side effects. icd-85, derived from the venom of two separate species of venomous animals, has been shown to exhibit anti-cancer activity. in this report polymer based sodium alginate nanoparticles of icd-85 was used to enhance its therapeutic effects and redu...

Skin photodamage, which is induced by ultraviolet (UV) radiation, a prevalent cause of skin damage. In this study, transdermal drug delivery system developed for the topical treatment composed tetrahedral framework nucleic acids (tFNAs) and lipoic acid (LA). The tFNAs-LA (TLA) nanocomposite exhibits excellent biocompatibility, as well antioxidant, anti-apoptotic, anti-inflammatory capabilities....


 Purpose: To determine the antitumor effect of demethoxycurcumin on lung cancer cells, as well its PI3K/AKT/m-TOR signalling, cellular apoptosis, cell migration and invasion.
 Methods: Cell viability was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, while AO/EB annexin V/PI staining assays were used for apoptosis analysis in demethoxycurc...

In the classic 'two-signal' model for B cell activation, signal 1 through the antigen receptor plus signal 2 through lymphokine receptors and CD40 leads to proliferation, but signal 1 alone leads to tolerance or anergy. In a protocol designed to deliver signal 1 in vitro with anti-delta without signal 2, purified small dense B cells from untreated mice exposed to any of three monoclonal anti-de...

Background Oleanolic acid (OA) has notable anti-inflammatory and anti-tumor effects, but the role of OA in cerebral ischemia-reperfusion injury (CIRI) not been reported so far. Methods Oxygen glucose deprivation/reoxygenation (OGD/R) model was induced PC12 cells. MTT assay used to detect cell viability cells, while ELISA detected expression TNF-?, IL-1? IL-6. The superoxide dismutase (SOD), mal...

The principal secretory product of the thyroid gland, L-thyroxine (T4), is anti-apoptotic at physiological concentrations in a number of cancer cell lines. Among the mechanisms of anti-apoptosis activated by the hormone are interference with the Ser-15 phosphorylation (activation) of p53 and with TNFα/Fas-induced apoptosis. The hormone also decreases cellular abundance and activation of proteol...

Cancer remains to be a major global healthcare burden as 18.1 million new cases and 96 death occurred 2018 on the basis of report from international agency for research cancer Breast is most common diagnosed in women causing highest morbidity. Ipomoea carnea leaf extracts have been used chemotherapeutic agent due their antioxidant, anti-inflammatory, anti-bacterial, anti-tumor effect. The aim s...

Background: Methyl jasmonate is a bioactive oxylipid that participates in the defense-related mechanisms of plants. The anti-inflammatory and anti-oxidative capacities methyl against lipopolysaccharide (LPS) induced arthritis have been widely investigated. However, role LPS-induced cell model tubular-interstitial nephritis (TIN) has not reported. Methods: LPS (5 µg/mL) was applied to treat huma...