BACKGROUND Brucea javanica (B. javanica) seeds, also known as "Melada pahit" in Indo-Malay region are traditionally used to treat diabetes. The objective of this study was to determine antidiabetic, antioxidant and anti-inflammatory effects of B. javanica seeds on nicotinamide (NA)-streptozotocin (STZ) induced type 2 diabetic (T2D) rats and to analyze its chemical composition that correlate wit...

Recent epidemiological studies suggest that postprandial hyperglycemia is an independent risk factor for cardiovascular disease. A human’s high carbohydrate diet majorly consists of a and α-glucosidase glucosidase located in the brush border small intestine involved glycosidic cleavage starch at α-glycosidic bonds. inhibitors are unique class anti-diabetic drugs particularly useful individuals ...

In this study, the chemical composition and antioxidant antidiabetic properties of S. elaeagnifolium flower (SEFl), fruit (SEFr), leaf (SEFe) extracts were investigated in vitro silico. HPLC-DAD analysis was used to determine components. Colorimetric techniques identify polyphenols flavonoids. The capacity determined using DPPH TAC assays. activity examined enzymes α-amylase α-glucosidase. Mole...

BACKGROUND Albizzia Lebbeck Benth. is traditionally important plant and is reported to possess a variety of pharmacological actions. The present research exertion was undertaken to isolate and characterized the flavonoids from the extract of stem bark of Albizzia Lebbeck Benth. and to evaluate the efficacy of the isolated flavonoids on in-vitro models of type-II diabetes. Furthermore, the resul...

Abstract. Maser WH, Maiyah N, Nagarajan M, Kingwascharapong P, Senphan T, Ali AMM, Bavisetty SCB. 2023. Effect of different extraction solvents on the yield and enzyme inhibition (a-amylase, a-glucosidase, lipase) activity some vegetables. Biodiversitas 24: 3320-3331. The present study investigated in vitro a-amylase, lipase, antioxidant activities (DPPH, metal chelating, FRAP) Allium cepa L., ...

The major goal in the treatment of diabetes mellitus is to achieve near-normal glycemic control. To optimize both fasting blood glucose and postprandial glucose levels is important in keeping blood glucose levels as close to normal as possible. alpha-Glucosidase is the enzyme that digests dietary carbohydrate, and inhibition of this enzyme could suppress postprandial hyperglycemia. The purpose ...

Objective: Alpha-glucosidase, as a carbohydratase catalyses the liberation of alpha-glucose from the nonreducing end of some carbohydrates from foods in digestive tract.  Consequently, retard absorption of glucose by the inhibition of carbohydrate hydrolyzing enzymes is one of the therapeutic approaches to decrease the postprandial hyperglycemia. Recently, a great deal of attention has been pai...