comparative study on toxoplasma serology among hiv positive and hiv negative illicit drug users in ahvaz, iran

The HIV-1causes life-threatening infection by establishing essential biochemical interactions via its IN protein with human host LEDGF/p75 protein. The crystal structure availability of LEDEF–HIV-IN complex provide essential roadmap for designing small drug-like molecule to perturb pathogen-host proteins interaction. We adopted the in-silico drug discovery approaches and scanned the TIMBAL data...

Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Seven 4-phenylchromen-2-one derivatives showed HIV transcriptional inhibitory ...

Human Immunodeficiency Virus (HIV) is the etiological agent of Acquired Immunodeficiency Syndrome (AIDS). There are 2 types of HIV: HIV-1 and HIV-2. However, worldwide, predominant virus is HIV-1. The development of safe, effective and low cost anti-HIV drugs is among the top global priorities of drug development since the disease is not yet curable, significant toxicity of available anti-HIV d...

Background Tuberculous meningitis (TBM) is the most severe form of tuberculosis. Co-infection with HIV increases the risk of developing TBM, complicates treatment, and substantially worsens outcome. Whether corticosteroids confer a survival benefit in HIV-infected patients with TBM remains uncertain. Hepatitis is the most common drug-induced serious adverse event associated with anti-tuberculos...

Adenoviruses (ADVs) are causative agents of severe and extremely contagious ocular and genital infections associated with conjunctivitis, genital ulcers and urethritis. Yet, no functional antiviral compounds are currently available against adenoviral infections. We discovered halogen-substituted phenyl phosphoramidate derivatives of stavudine (STV/d4T) as a new class of dual-function anti-human...

HIV-1 protease (HIV-pr) acts as the most promising drug target commonly used for anti-HIV therapy. However, efficiency of inhibitors (PIs) has been greatly reduced by mutations assisted resistance. Because richness and greatest diversity plants, current study aims at exploring phytocompounds PIs with potential inhibitory properties against HIV-pr through multi-faceted in silico tactics. Virtual...

A randomized, double-blind, placebo-controlled, dose-escalation study of adefovir dipivoxil, an oral prodrug of adefovir, was conducted in 36 human immunodeficiency virus (HIV)-infected subjects to evaluate its anti-HIV activity, safety, and pharmacokinetics. Subjects received placebo or one of three dosages of adefovir dipivoxil daily for 14 days. Median decreases in serum p24 antigen of 31% (...