Donald R. Roberts, Ph.D. Professor Emeritus, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA describes the successful history of the use of DDT for the eradication of malaria and how single issue anti-DDT campaigners have compromised the success of this programme. Email:[email protected] Contact information:118 First St, Clifton Forge, VA 2...

BACKGROUND Apical membrane antigen 1 (AMA1) is one of the best-studied blood-stage malaria vaccine candidates. When an AMA1 vaccine was tested in a malaria naïve population, it induced functionally active antibodies judged by Growth Inhibition Assay (GIA). However, the same vaccine failed to induce higher growth-inhibitory activity in adults living in a malaria endemic area. Vaccination did ind...

Erythrocytes infected with mature stages of Plasmodium falciparum express variant surface antigens (VSAs) of parasite origin, including P. falciparum erythrocyte membrane protein 1. Anti-VSA antibodies protect against clinical malaria caused by parasites bearing VSAs to which they are specific (homologous), but their role in protecting against heterologous infection is unclear. Here, we report ...

Anti-malarial drugs have been used in various ways to prevent malaria in the resident populations of endemic areas for nearly 100 years. The primary aim of most early studies was to interrupt transmission. This was rarely achieved, but administration of anti-malarial drugs either through medication of salt or by mass administration frequently led to a marked reduction in the prevalence of malar...

Medical officers in each local body were responsible for their respective areas. Fortnightly meetings of all the medical officers concerned were held at the Malaria Survey Office, Delhi, where Colonel Covell or Major Afridi, i.m.s. (special anti-malaria officer, Delhi), kept the medical officers fully posted with information about conditions prevailing in the various areas and about any danger ...

To prevent and control infectious diseases was one of the major concerns of U.S. military government when they stationed in Korea in 1945. It was because the spread of various infectious diseases can cause social unrest and they can also affect the U.S. military. Malaria was one of the most important infectious diseases to which the U.S. military had been paying special attention. The U.S. mili...