Aggregation, red-NIR emission and light-up upon nucleic acid G-quadruplex binding have been investigated for a prototype core-extended naphthalene diimide, which is capable of fast cellular entry and nucleolar localization. Both high-level colocalization with an anti-G-quadruplex antibody and nucleolin displacement reveal that the compound targets and thus makes visible nuclear DNA G-quadruplexes.

Structuring the information and knowledge needed to implement a factory, as well as doing its control and management by computer systems, is the purpose of the meta-model and solutions here presented. This meta-model includes: an object-oriented model to structure the needed information and knowledge; a model for manufacturing systems; a prototype that integrates the two previously referred mod...

This paper is an introduction to the short story and science fiction prototype The Machinery of Love and Grace. We cover a brief overview of the goals of science fiction prototyping as well as an example for how both Albert Einstein and Sigmund Freud used a very similar process to achieve greatness in their work. Finally we look into the specific science behind the story The Machinery of Love a...

........................................................................................................................ 1 OBJECTIVE ....................................................................................................................... 2 BACKGROUND ................................................................................................................ 2 TASK 1. OPTIMIZA...

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This paper presents a prototype, not completely operational, that is intended to use c-graphs in the translation of assemblers. Firstly, the formalization of the structure and its principal notions (substructures, classes of substructures, order, etc.) are presented. Next section describes the prototype which is based on a Transformational System as well as on a rewriting system of c-graphs whi...

seaweeds have caused an emerging interest in the biomedical area, mainly due to their contents of bioactive substances which show great potential as anti-inflammatory, anti-microbial, anti-viral and anti-tumoral drugs. despite the diversity in quality and quantity of the mediterranean tunisian coast flora, with its large contains of marine organisms and seaweeds, most of them have not yet been ...