fenugreek (trigonella foeum-graecum l.) has been used in iranian traditional medicine for treatment of different kinds of inflammation disorders. in the present study, anti- inflammatory activity of the methanolic extract of the plant (at doses of 100, 200 and 400 mg/kg) were studied using carrageenan-induced edema method and compared with the effects of dexamethasone and ibuprofen. various con...

OBJECTIVES Nebulized hypertonic saline (HTS) has beneficial effects including reducing pulmonary exacerbations in Cystic Fibrosis (CF) patients. Several mechanisms may explain these effects but antimicrobial activity of NaCl remains largely unexplored. We aimed to measure the antimicrobial effect of NaCl on Pseudomonas aeruginosa isolated from the respiratory tract in CF patients. METHODS NaC...

objective(s): biological applications of gold nanoparticles have limitations because of the toxic chemicals used in their synthesis. curcumin can be used as reducing as well as capping agent in synthesis of gnps to eliminate the cytotoxicity. conjugation of curcumin to gold also helps in increasing its solubility and bioavailability. materials and methods: here we report synthesis of gold nanop...

the anti-ischemic effect of aqueous and ethanolic extracts of nigella sativa l. seed was studied using a four-vessel occlusion model in rats. the ischemia was evaluated by optical and transmission electron microscopy. after 20 min of forebrain ischemia, agents were administered intraperitoneally after reperfusion. both extracts comprised an alkaloid. in ischemic rats, the aqueous (1 g/kg) and e...

background: asthma is a chronic inflammatory disorder of the airways. the available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. myrica sapida is known traditionally in...

Pseudomonas elastase (LasB), a metalloprotease virulence factor, is known to play a pivotal role in pseudomonal infection. LasB is secreted at the site of infection, where it exerts a proteolytic action that spans from broad tissue destruction to subtle action on components of the host immune system. The former enhances invasiveness by liberating nutrients for continued growth, while the latter...

BACKGROUND Overnight orthokeratology was thought to be a safe and non-invasive alternative for low-grade myopia and astigmatism correction. We assessed histories, clinical courses, and visual outcomes of the patients with pseudomonal keratitis related to overnight orthokeratology. METHODS The records of six patients with pseudomonal keratitis related to overnight orthokeratology were reviewed...