The reported cases of snake bite are 5.4 million per year, making the serious envenoming issue so, that WHO categorises in neglected tropical diseases. Anti venom is produced by intramuscular injection crude with different formulation adjuvants to equine animals, but these injections have several health impact equine. Snake species categorised according geographical locations, and there ...

The hydrolytic action of snake venom phosphodiesterase on poly(adenosine diphosphate ribose) was investigated in comparison with that of rat liver phosphodiesterase. The purified polymer, labeled with s2P or 14C, was partially hydrolyzed with snake venom phosphodiesterase and passed through a Sephadex G-50 column. The resulting elution profiles showed the existence of degradation products with ...

OBJECTIVE Snake bite remains major public health problem worldwide. We present our experience with cases of snake bites managed in our tertiary care teaching center of South India. MATERIALS AND METHODS The details of all patients with snake bite admitted to a tertiary teaching care hospital from 2010 to 2012 were retrospectively retrieved and reviewed. The details regarding age, gender, firs...

Snake bite cases in Malaysia most often involve the species Naja-naja and Calloselasma rhodostoma. In keeping with the need for a rapid snake venom detection kit in a clinical setting, plate and dot-ELISA test for the venoms of Naja-naja sumatrana, Calloselasma rhodostoma and the cobra venom fraction V antigen was developed. Polyclonal antibodies were raised and further used to prepare the reag...

4 hours after the snake bite, when there has been ample time to exhaust endogenous clotting factors.3 Furthermore, the rate of recovery (based on INR) after antivenom treatment is expected to correlate with resynthesis of the consumed clotting factors. Notably, no reference was made to prothrombin levels after envenomation.3 We speculate that this information could provide greater insight into ...

Attempts to reconstruct the evolutionary history of snake toxins in the context of their co-option to the venom gland rarely account for nonvenom snake genes that are paralogous to toxins, and which therefore represent important connectors to ancestral genes. In order to reevaluate this process, we conducted a comparative transcriptomic survey on body tissues from a venomous snake. A nonredunda...

Two young patients are described who made complete recovery from locked-in syndrome (LIS) after snakebites. LIS was a presenting feature in a patient of presumed snake bite who showed complete response to polyvalent Anti-snake venom (ASV). This case suggests that elapid snake bite should be suspected in unresponsive patient found in early morning in endemic areas of snake bite in monsoon season...

Elapid snake venom is a highly valuable, but till now mainly unexplored, source of pharmacologically important peptides. We analyzed the peptide fractions with molecular masses up to 10 kDa of two elapid snake venoms-that of the African cobra, N. m. mossambica (genus Naja), and the Peninsula tiger snake, N. scutatus, from Kangaroo Island (genus Notechis). A combination of chromatographic method...

Only few studies on snake venoms were dedicated to deeply characterize the toxin secretion of animals from the Colubridae family, despite the fact that they represent the majority of snake diversity. As a consequence, some evolutionary trends observed in venom proteins that underpinned the evolutionary histories of snake toxins were based on data from a minor parcel of the clade. Here, we inves...

abstract background and objective: snake venom is a complex of several toxic elements and enzymes. it has the agents with the ability to destroy cellular and subcellular membrane and to bring about hemolysis of red blood cells (rbc). two types of direct and indirect hemolytic activity are known in snake venom in that phospholipase a2 is responsible for the indirect lysis. the aim of this study ...