نتایج جستجو برای: antibacterial drug
تعداد نتایج: 625588 فیلتر نتایج به سال:
Growing resistance to antibacterial agents has increased the need for the development of new drugs to treat bacterial infections. Given increasing pressure on limited health budgets, it is important to study the cost-effectiveness of these drugs, as well as their safety and efficacy, to find out whether or not they provide value for money and should be reimbursed. In this article, we systematic...
Diclofenac 2(2,6 dichloranilino) phenylacetic acid is a widely prescribed non-steroidal anti inflammatory drug. It is used to reduce pain and treat inflammation in some disorders like rheumatoid arthritis, osteoarthritis, ankylosing spondilytis, gout, dysmenorrhea, spondylarthritis etc., It acts by inhibiting the action of cycloxygenase enzymes COX-1 and COX-2 which are responsible for the synt...
A new high throughput antibacterial method employing the dye resazurin as an indicator of bacterial growth was developed to evaluate drug susceptibility by combined measurements of microtitre-plates, colorimetric and haemocytometric assays. The bacterial strains E. coli, B. subtilis, P. aeruginosa and S. aureus (multi-drug resistant strain) were used to evaluate the preliminary screening of pla...
The pharmacokinetics of the quinolone enoxacin were studied after a 600-mg oral dose was given to each of six male volunteers. The levels of the compound were measured in serum, blister fluid, and urine. Absorption was variable, with peak levels (mean, 3.7 micrograms/ml) being attained between 0.75 and 3.0 h (mean, 1.9 h). The serum elimination half-life was 6.2 h, and 71.6% of the drug was rec...
With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. We report here the discovery and X-ray crystallographic structures of 10 chemically diverse compounds (benzoic, diketo, and phosphonic acids, as well as a bisamidine and a bisamine) that inhibit bacterial undecaprenyl diphosphate synthase, an essential enzyme involved in cell wall biosynthesis. The in...
There is a significant need for new antibiotics due to the rise in drug resistance. Drugs such as methicillin and vancomycin target bacterial cell wall biosynthesis, but methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) have now arisen and are of major concern. Inhibitors acting on new targets in cell wall biosynthesis are thus of particular interest ...
PURPOSE The purpose of this study was to determine possible genotoxic effects of a new very promising antibacterial/antiviral drug FS-1. METHODS The drug was tested in TA98, TA100, TA102, TA1535 and TA1537 strains of Salmonella (Ames test) with and without metabolic activation, and also in mouse lymphoma L5178Y cells by means of micronucleus and comet assays. In microbes the drug was tested a...
background many efforts have been made by researchers to find new antibiotics which are clinically useful against bacteria and drug resistant microorganisms. objectives we aimed to evaluate the antimicrobial effects of hydroalcoholic extracts of leaves and seeds of the portulaca oleracea plant in traditional medicine of sistan region, southeast of iran. materials and methods in this cross-secti...
abstractthe aim of the present study was to formulate poly (lactide-co-glycolide) (plga) nanoparticles loaded with 18-β-glycyrrhetinic acid (gla) with appropriate physicochemical properties and antimicrobial activity. gla loaded plga nanoparticles were prepared with different drug to polymer ratios, acetone contents and sonication times and the antibacterial activity of the developed nanopartic...
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