INTRODUCTIONS In the past 50 years, antibiotics became an important part of our everyday lives: we take them during routine visits to dental and doctor offices, but they are also invisibly present on supermarket produce shelves. If asked around, one would probably hear as many definitions of the word “antibiotic” as there are uses for these powerful drugs. However, this everyday presence was re...

The era of the "classical antibiotic" may be over. The emergence of resistance has seen to that. Yet no truly novel class of antibacterial agent has come on the market in the past 30 years. Currently there is great interest in peptide antibiotics, especially the cationic peptides. Thousands of such molecules have been synthesised and just a few are entering clinical trials. Because they kill ba...

A novel endopeptidase degrading the pel)tide cross-links in sacculi has been isolated from Escherichia coli and purified to homogeneity. I'lhe enzyme has a molecular weight of 30,000 and, in contrast to already known enzymes of similar specificity, remains fully active in the presence of/3-lactam antibiotics. In adldition, it is exceptional in being inhibited by single-strandetl tleoxyribonucle...

Administration of medications via aerosolization is potentially an ideal strategy to treat airway diseases. This delivery method ensures high concentrations of the medication in the targeted tissues, the airways, with generally lower systemic absorption and systemic adverse effects. Aerosolized antibiotics have been tested as treatment for bacterial infections in patients with cystic fibrosis (...

Aminoglycosides are hydrophilic, polycationic, aminecontaining carbohydrates that are usually composed of three to five rings. Most aminoglycosides are either natural products or derivatives of soil actinomycetes. They are often secreted by these actinomycetes as mixtures of closely related compounds. The polycationic aminoglycoside chemical structure results in a binding both to the anionic ou...

upflow anaerobic sludge blanket (uasb) reactors have been widely used for treatment of industrial wastewater. in this study, performance of a lab-scale up-flow anaerobic sludge blanket (uasb) reactor, treating a chemical synthesis-based pharmaceutical wastewater, was evaluated under different operating conditions. a (p.e) pipe with a diameter of 250 mm and total height of 120 cm and effective h...

persistent microorganisms in the root canal are known to cause endodontic treatments failure. overextended gutta-percha can also act as a periradicular tissue irritant, leading to large periapical lesions. retrieval of overextended gutta-percha with a nonsurgical approach can prove to be a challenge. this case describes the nonsurgical management of a large periapical lesion associated with ove...

objective(s) a sensitive liquid chromatographic method for the analysis of clarithromycin- a macrolide antibiotic- in human serum, using pre-column derivatization with 9-fluorenylmethyl chloroformate (fmoc-cl) is described. materials and methods the method involved liquid-liquid extraction of the drug and an internal standard (amantadine) followed by pre-column derivatization of the analytes wi...

introduction: infection is the most common complication of burn and one of the most important causes of mortality and morbidity in burned patients. topical antibiotics have important role in prevention and treatment of infection and reduction of mortality in burned patients. increases of use of antibiotics cause microbial resistance. methods: to determine microbial resistance to three topical a...