Anticonvulsant drugs were given to 70 patients suffering from lancinating pains of various clinical aetiologies. Serum drug estimations were used to ensure that an effective dose level was achieved. In about 66% of the cases, treatment produced some diminution in the intensity and/or frequency of the "flashes" of pain. The neurophysiological and pharmacological rationales are briefly explained....

ATTENTION has been drawn to the possible adverse effects of anticonvulsant drugs on bone metabolism by a number of reports in recent years (Dent et al, 1970; Richens and Rowe, 1970; Hunter et al, 1971; Lifshitz and Maclaren, 1973; Stamp, 1974; British Medical Journal, 1976). The aim of the present study was to investigate this potentially serious side-effect of anticonvulsant therapy in the set...

Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet). N-methyl-5-bromo-3-(p-chlorophenylimino) isatin (2) exhibited anticonvulsant activity in MES and ScMet with LD50 > 600 mg kg(-1), showing better activity than the standard drugs...

Introduction: Epilepsy is one of the most common neurologic disorders. Pharmacoresistance and adverse effects of current antiepileptic drugs (AEDs) necessitate development of new drugs and strategies for treatment of epilepsy. Omega 3-Polyunsaturated fatty acids (ω3-PUFAs) are safe nutritional supplements that recently considered for treatment of epilepsy. Anticonvulsant effect of docosahexa...

Caffeine has been reported to be proconvulsant and to reduce the anticonvulsant efficacy of a variety of antiepileptic drugs (carbamazepine, phenobarbital, phenytoin, valproate and topiramate) in animal models of epilepsy and to increase seizure frequency in patients with epilepsy. Using the mouse maximal electroshock model, the present study was undertaken so as to ascertain whether caffeine a...

Background Surgeries causing nerve injury can result in chronic neuropathic pain, which is clinically managed by using antidepressant or anticonvulsant drugs. Currently, there is a growing interest for investigating preemptive treatments that would prevent this long-term development of neuropathic pain. Our aim was to compare analgesic drugs using two distinct treatment modalities: either treat...

BACKGROUND Losartan and telmisartan, angiotensin AT1 receptor antagonists, are widely used antihypertensive drugs in patients. It is also known that arterial hypertension is often present in people with epilepsy, therefore, drug interactions between AT1 receptor antagonists and antiepileptic drugs can occur in clinical practice. OBJECTIVES The aim of the current study was to assess the effect...

DESPITE the high incidence of convulsive disorders and widespread use of shock therapy in the major psychoses, relatively few investigations have dealt with the physiological properties of experimental seizures (1, 2, 3, 10, 12, 14, 16, 17). Convulsive threshold has received considerable attention, particularly in the testing of anticonvulsant drugs (11, 13, 15, 18, 21, and others), but thresho...