نتایج جستجو برای: anticonvulsive drugs

تعداد نتایج: 224417  

Journal: :Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2008
Alexander Rotenberg Paul Muller Daniel Birnbaum Michael Harrington James J Riviello Alvaro Pascual-Leone Frances E Jensen

OBJECTIVE To test the anticonvulsive potential of a range of repetitive transcranial magnetic stimulation (rTMS) frequencies by novel methods for simultaneous EEG and rTMS in a rat seizure model. METHODS Seizures were triggered by intraperitoneal kainic acid (KA; 10mg/kg). Rats (n=21) were divided into three groups in which individual seizures were treated with rTMS trains at one of three fre...

2012
Hitomi Hino Hisaaki Takahashi Yuka Suzuki Junya Tanaka Eiichi Ishii Mitsumasa Fukuda

Febrile seizures (FS) is the most common convulsive disorder in children, but there have been no clinical and experimental studies of the possible treatment of FS with herbal medicines, which are widely used in Asian countries. Paeoniflorin (PF) is a major bioactive component of Radix Paeoniae alba, and PF-containing herbal medicines have been used for neuromuscular, neuropsychiatric, and neuro...

Journal: :Polish journal of pharmacology 2002
Kinga K Borowicz Jarogniew Luszczki Mariusz Matuszek Zdzisław Kleinrok Stanisław J Czuczwar

The aim of this study was to evaluate the efficacy of three antihormones, tamoxifen (TXF, an antiestrogen), mifepristone (MIF, an antiprogesterone) and cyproterone (CYP, an antiandrogen) in two major models of experimental epilepsy, electrically and pentetrazole (PTZ)-evoked seizures in mice. TXF (20-50 mg/kg) significantly raised the threshold for electroconvulsions in female mice, whereas CYP...

2009
R. Fallah

R. Fallah MD Abstract: Objective Refractory convulsive Status Epilepticus (SE) which does not respond to first line drugs (benzodiazepines, phenytoin and phenobarbital) heralds an emergency condition in pediatric neurology which can cause irreparable brain damage. There is no consensus on the choice of drug treatment for refractory generalized convulsive status epilepticus in children. Lidocain...

Journal: :Archives of disease in childhood 1981
Y Morijiri T Sato

An epidemiological study on vitamin D-dependent rickets was carried out in severely handicapped institutionalised children on long-term anticonvulsant therapy. Nine (10%) of 94 patients had overt rickets on the basis of roentgenological bone changes and biochemical indices, but 46 patients in hospital without medication, and 50 epileptic patients attending an outpatient clinic and taking antico...

2016
Álvaro Sebastián-Serrano Tobias Engel Laura de Diego-García Luis A. Olivos-Oré Marina Arribas-Blázquez Carlos Martínez-Frailes Carmen Pérez-Díaz José Luis Millán Antonio R. Artalejo María Teresa Miras-Portugal David C. Henshall Miguel Díaz-Hernández

Hypomorphic mutations in the gene encoding the tissue-nonspecific alkaline phosphatase (TNAP) enzyme, ALPL in human or Akp2 in mice, cause hypophosphatasia (HPP), an inherited metabolic bone disease also characterized by spontaneous seizures. Initially, these seizures were attributed to the impairment of GABAergic neurotransmission caused by altered vitamin B6 (vit-B6) metabolism. However, clin...

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