Juniperus communis (Cuppraseae), a coniferous plant widely used as traditional medicine was evaluated for the antidiabetic and antihyperlipidemic activity on Streptozotocin(STZ)-nicotinamide induced diabetic rats. The methanolic extract of Juniperus communis (MEJC) (100mg/kg, 200mg/kg, b.w) was administered orally in diabetic group except the standard group (Glibenclamide 10mg/kg, b.w) and the ...

Diabetes mellitus remains a burden worldwide in spite of the availability of numerous antidiabetic drugs. Honey is a natural substance produced by bees from nectar. Several evidence-based health benefits have been ascribed to honey in the recent years. In this review article, we highlight findings which demonstrate the beneficial or potential effects of honey in the gastrointestinal tract (GIT)...

Present study was aimed to isolate and evaluate the antidiabetic activity of phytoconstituents from fruit rinds of Punica granatum. With the above objectives Valoneic acid dilactone (VAD) was isolated from methanolic fruit rind extracts of Punica granatum (MEPG) and confirmed by (1)H-NMR, (13)C-NMR, and mass spectral data. Antidiabetic activity was evaluated by Aldose reductase, α-amylase and P...

Although antidiabetic agents have been developed to target one or more of the core defects of type 2 diabetes mellitus (T2DM), many patients do not achieve glycemic goals. Inhibition of the sodium-glucose cotransporter 2 (SGLT2) induces glycosuria, reduces glucose toxicity and improves insulin sensitivity and β-cell function. As the mechanism of action of SGLT2 inhibitors is different from othe...

Viscum album (mistletoe) has been documented as a traditional treatment of diabetes. In acute 20-min tests, 1-10 mg/ml aqueous extract of mistletoe evoked a stepwise 1.1- to 12.2-fold stimulation of insulin secretion from clonal pancreatic B-cells. This effect was abolished by 0.5 mM diazoxide and prior exposure to extract did not alter subsequent stimulation of insulin secretion induced by 10 ...

Vitamin E family constitutes of tocopherol and tocotrienol. Each form has several isomers: alpha,beta, gamma, delta, desmo and didesmo. Although tocopherol is known much earlier, tocotrienol has been discovered more recently.Tocotrienol has higher antioxidant potential than tocopherol. Research shows that tocotrienol can inhibit the induced oxidative damage to lipids and proteins. Cholesterol b...

Diabetes is the disease caused due to deficiency of insulin. Antidiabetic drug Gliclazide decreases blood glucose level by inducing insulin. Frequent administration of Gliclazide decreases patient compliance. The present study was aimed to formulate a sustained release formulation of Gliclazide, liposomes. Due to the sustained release property of liposomes it increases patient compliance. Ethan...

The root of Combretum dolichopetalum (Combreatacea) is used in ethnomedicine for the management of diabetes mellitus. Though some compounds have been isolated from it, the antidiabetic principles have not been identified. The present study was designed to evaluate the chemical constituents from the root of C. dolichopetalum with a view to identifying the antidiabetic principles. The constituent...