The petroleum ether, chloroform, acetone, methanol and aqueous extracts of the aerial parts of Leptadenia reticulata Wight and Arn. (Asclepiadaceae) were studied for in vitro antifungal activity against Aspergillus flavus, Aspergillus ruantti, Candida tropicalis, Candida albicans, Trichodermata viride and Trichodermata koningii respectively. The methanolic extract exhibited prominent antifungal...

Fungal infections are a main reason for the high mortality rate worldwide. It is a challenge to design selective antifungal agents with broad-spectrum activity. Lanosterol 14α-demethylase is an attractive target in the design of antifungal agents. Seven compounds were selected from a number of designed compounds using a rational docking study. These compounds were synthesized and evaluated for ...

Voriconazole is a second-generation azole antifungal agent that shows excellent in vitro activity against a wide variety of yeasts and molds. It can be given by either the intravenous or the oral route; the oral formulation has excellent bioavailability. The side effect profile of voriconazole is unique in that non-sight-threatening, transient visual disturbances occur in approximately 30% of p...

Posaconazole is the newest triazole antifungal agent. It is structurally related to itraconazole and has activity against Candida species, Aspergillus species, Cryptococcus neoformans, the zygomycetes, and other filamentous fungi. Randomized, double-blind trials have shown posaconazole to be at least as efficacious as fluconazole for the prevention of invasive fungal infections in immunocomprom...

aspergillus terreus is emerging as an etiologic agent of invasive aspergillosis among patients undergoing cancer chemotherapy, haematopoetic stem-cell transplantation, or solid organ transplantation worldwide. infections caused by aspergillus terreus has become important due to less susceptibility to antifungal drags, resistant to amphotericin b and therefore, poor clinical outcome and higher m...

Eight commonly used spices Syzygium aromaticum, Cinnamonum zeylanicum, Zingiber officinale, Murraya koenigii, Piper nigrum, Trachyspermum ammi, Allium sativum and Allium cepa were tested for in vitro antifungal activity on Aspergillus niger, a causative agent of different destructive disease. Out of eight plant materials used, five showed significant antifungal activity against the test pathoge...

The antifungal activity of eight different medicinal plants namely Aloe vera, Ocimum sanctum, Cenetella asiatica, Piper betle, Calotropis gigantea, Vitex negundo, Ocimum basilicum and Azadirachta indica were tested against plant pathogenic fungus (red rot disease causing agent) Colletotrichum falcatum by agar well –diffusion method. The plants leaves were extracted with various solvents like ch...