The incidence of invasive fungal infections is increasing in recent years. The present study mainly investigated glabridin (Gla) alone and especially in combination with fluconazole (FLC) against Cryptococcus neoformans and Candida species (Candida albicans, Candida tropicalis, Candida krusei, Candida parapsilosis and Candida Glabratas) by different methods. The minimal inhibitory concentration...

the interest in plants antimicrobial properties has been revived because of the current problems associated with the use of antibiotics. nowadays, the fact that microorganisms tend to develop drug resistance, besides the side effects of certain antibiotics has offered considerable potentials for the development of new effective antifungal and antioxidant agents; medicinal plants are prolific so...

BACKGROUND Emergence of resistance to respective antifungal drugs is a primary concern for the treatment of candidiasis. Hence, determining antifungal susceptibility of the isolated yeasts is of special importance for effective therapy. For this purpose, the clinical laboratory standard institute (CLSI) has introduced a broth microdilution method to determine minimum inhibitory concentration (M...

introduction: the aim of this study was to evaluate the effect of dentin on the antifungal activity of gray and white-colored mta (gmta, wmta) using a tube-dilution test. materials and methods: mta preparations were tested freshly mixed and after 24h on candida albicans (ca). the experiment was performed in 24-well culture plates. fifty wells were used and divided into four experimental groups ...

Objective. To evaluate in vitro antifungal activity of thiabendazole against strains of dermatophytes using a reference method for filamentous fungi. Materials and Methods. Dermatophytes' susceptibility to thiabendazole (TBZ) and fluconazole (FCZ) was evaluated using macrodilution method of protocol M38-A2 of the Clinical and Laboratory Standards Institute (CLSI). Results. MIC ranges of TBZ for...

The present work deals with the antifungal activity of SN 105-843 (Naftifine) against dermatophytes in vivo. Fifty cases suffering from various types of dermatomycoses were studied from November 1979 to September l980. The patients were supplied with 1% gel preparation of SN 105-843 for local application on the lesion for a period of 2-8 weeks. The results indicate that the drug has very signif...

FR227244 is a novel triterpene glycoside that exhibits in vitro antifungal activity against filamentous fungi such as Aspergillus sp. and Trichophyton sp. and yeast such as Candida utilis and Candida parapsilosis but shows low activity against Candida albicans, Candida krusei and Candida tropicalis. Specifically, FR227244 exhibits in vitro and in vivo antifungal activity against Aspergillus fum...

Two essential oils of Lippia alba (Mill.) N.E. Brown (Verbenacea), the carvone and citral chemotypes and 15 of their compounds were evaluated to determine cytotoxicity and antifungal activity. Cytotoxicity assays for both the citral and carvone chemotypes were carried out with tetrazolium-dye, which showed a dose-dependent cytotoxic effect against HeLa cells. Interestingly, this effect on the e...