BACKGROUND In previous studies, the relaxant, anticholinergic (functional antagonism) and antihistaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains. To elucidate the other mechanisms responsible for the relaxant effect of this plant, its inhibitory effect on the calcium channel was examined in this study. RESULTS The inhibitory effects of both concentration...

The aim of the investigation was to throw light on the question whether drugs other than antibiotics and chemotherapeutic agents exert an antimicrobial effect. In order to elucidate this, the antimicrobial effect of selected psychotherapeutic drugs and their stereo-isomeric analogues was studied. The development of psychotherapeutic drugs from aniline dyes has been reviewed against the backgrou...

Roche, Silva and Antonio (3) showed that there is production of oedema in animals exposed to a temperature of 44°·45°C for twenty to thirity minutes and there is release of body bradykinin. The possibility of 5-HT and histamine being responsible for such an oedema is ruled out firstly by the fact that the mast cells get stablized at this temperature and secondly the antihistaminic and antiserot...

The MeOH extract of Asarum sagittarioides (Aristolochiaceae) showed antihistaminic activity. N-Isobutyl-3,4-methylenedioxybenzamide (1) was isolated as the active principle, and this compound was proved to be an antiallergic substance by pharmacological studies. Furthermore, in order to investigate the structure-activity relationships, some analogues of 1 were synthesized, and compounds 4 and 5...