cu-Melanocyte-stimulating hormone (a-MSH,.,,) and its COOHterminal tripeptide ol-MSH,,.,, (Lys Pro Val) inhibit inflammation when administered systemically. Recent evidence indicates that c~-MSH,.,, can likewise inhibit inflammation in the skin solely via an action within the brain. Because of the potential importance of this discovery to understanding the control of inflammation and because (u...

Objective To investigate factors that together with hand or hip/knee osteoarthritis (OA) could contribute to functional decline over a year’s time in elderly individuals. Methods The data of 1,886 individuals between ages 65 and 85 years prospective, observational population-based study 12–18 months follow-up the context European Project on Osteoarthritis were analyzed. outcome measures self-re...

Glucocorticoids, since their spectacular introduction into clinical medicine in 1948 (1), remain a classically efficient treatment for arthritis and other inflammatory conditions (2). Indeed, the discoverers of this therapy were awarded an immediate Nobel Prize. Since then, glucocorticoids have remained a cornerstone in the treatment of chronic inflammation, and despite the introduction of nove...

BACTERIAL KERATITIS Simple, uninfected cases of corneal ulceration can be treated with prophylactic antibiotics, mydriatics and systemic antiinflammatory agents. However, aggressive medical therapy is indicated in all cases of confirmed or suspected bacterial keratitis. This includes topical and systemic antimicrobial drugs, mydriatics and antiproteases, and sysemic non-steroidal antiinflammato...

several studies point to an important function of cyclooxygenase (cox) and prostaglandin signaling in models of synaptic plasticity which is associated with n-methyl-d-aspartate receptors (nmdars). cyclooxygenase gene is suggested to be an immediate early gene that is tightly regulated in neurons by nmda dependent synaptic activity. nonsteroid antiinflammatory drugs (nsaids) exert their antiinf...

Aceclofenac (AC) is an effective non-steroidal antiinflammatory drug, which possesses remarkable antiinflammatory, analgesic and antipyretic properties. The analgesic and anti-inflammatory efficacy of AC is generally equivalent to that of comparator nonsteroidal antiinflammatory drugs (NSAIDs) with similar onset of action. AC also shows stimulatory effects on glycosaminoglycan synthesis in huma...

Antiinflammatory therapy for chronic obstructive pulmonary disease (COPD) can be directed at several stages of the inflammatory process. Much attention has been focused on blocking the damaging effects of toxic mediators released by inflammatory cells, including antioxidants and antiproteases. An alternate strategy is to block the recruitment of inflammatory cells into the lung, such as by inhi...