Mutual prodrugs of some antiinflammatory agents were synthesized with the aim of improving the therapeutic index through prevention of gastrointestinal complications and to check the efficiency of release of the parent drug in presence of spacer. These mutual prodrugs were synthesized by direct condensation method using dicyclohexyl carbodiimide as a coupling agent and glycine as a spacer. The ...

To evaluate the effects of antimicrobial and antiinflammatory drugs on oviductal pathology in chronic chlamydial upper genital tract infection, the fallopian tubes of 40 female Macaca nemestrina were inoculated with Chlamydia trachomatis and randomly assigned to treatment with doxycycline (n = 10), doxycycline plus ibuprofen (n = 10), doxycycline plus triamcinolone (n = 10), or placebo (n = 10)...

PURPOSE To review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories. METHODS A comprehensive literature survey. RESULTS AND CONCLUSION Keratoconjunctivitis Sicca (KCS) is a multifactorial and complex disorder in which ocular surface in...

Rheumatoid arthritis is a common and potentially devastating condition which did not have good treatment options until recently. Pharmacological treatment should not just comprise antiinflammatory agents and corticosteroids. The current therapeutic approach is to start a disease modifying agent early in the illness to prevent eventual joint damage. Older disease modifying anti-rheumatic drugs (...

Overactive bladder (OAB) is a syndrome involving urinary urgency with accompanying increased daytime urinary frequency and nocturia, with or without urgency urinary incontinence, in the absence of an urinary tract infection or other obvious pathology. The detailed OAB pathophysiology remains unclear. There is evidence that OAB pathogenesis also includes abnormal bladder paracrine activity, asso...

Immuno-enhancing actions of carnosine, beta-alanine, homocarnosine, and gamma-aminobutyric acid were studied in ddY mice by evaluating plaque-forming cell reaction against sheep red blood cells. Animals were administered the test agents in prior to, or simultaneously with, various treatments that are known to reduce immune function such as administration of the anti-tumor agents, mitomycin C an...

The use of steroids in the acute and emergency conditions of inflammation is well established. Most of the time they are given chronically to the patients with arthritis. The present study focuses on developing substantial quantitative structure activity relationship models of certain steroidal derivatives reported to be as anti-inflammatory agents. The QSAR models of androstene derivatives wer...

To the Editor—In their commentary, Chan et al propose that angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) should be considered first-choice antihypertensive therapies for obese patients, given the favourable effects of these agents on glucose metabolism. We agree with this assertion and suggest that the antiinflammatory action of renin-angiotensin blocka...

The hepatotoxic potential of diclofenac, a commonly used non-steroidal antiinflammatory agent, is well established in literature. However, cases diclofenacinduced liver disease have occurred almost exclusively with the oral formulation this medication. We report case an elderly man Paget’s and osteoarthritis who developed acute hepatotoxicity, as evidenced by laboratory diagnostics, four months...