نتایج جستجو برای: antileishmanial activity

تعداد نتایج: 1134874  

2014
R. Mogana A. Adhikari S. Debnath S. Hazra B. Hazra K. Teng-Jin C. Wiart

In continuation of our natural and medicinal research programme on tropical rainforest plants, a bioassay guided fractionation of ethanolic extract of leaves of Canarium patentinervium Miq. (Burseraceae Kunth.) led to the isolation of scopoletin (1), scoparone (2), (+)-catechin (3), vomifoliol (4), lioxin (5), and syringic acid (6). All the compounds exhibited antiacetylcholinesterase activity ...

2014
Luciana Costa Roberta O. Pinheiro Patrícia M. L. Dutra Rosiane F. Santos Edézio F. Cunha-Júnior Eduardo C. Torres-Santos Alcides J. M. da Silva Paulo R. R. Costa Silvia A. G. Da-Silva Ger van Zandbergen

Previous results demonstrate that the hybrid synthetic pterocarpanquinone LQB-118 presents antileishmanial activity against Leishmania amazonensis in a mouse model. The aim of the present study was to use a hamster model to investigate whether LQB-118 presents antileishmanial activity against Leishmania (Viannia) braziliensis, which is the major Leishmania species related to American tegumentar...

Journal: :Antimicrobial agents and chemotherapy 2015
Dhiman Sankar Pal Dipon Kumar Mondal Rupak Datta

Dithiocarbamates have emerged as potent carbonic anhydrase (CA) inhibitors in recent years. Given that CAs are important players in cellular metabolism, the objective of this work was to exploit the CA-inhibitory property of dithiocarbamates as a chemotherapeutic weapon against the Leishmania parasite. We report here strong antileishmanial activity of three hitherto unexplored metal dithiocarba...

Journal: :Antimicrobial agents and chemotherapy 2005
Denise C Arruda Fabio Luiz D'Alexandri Alejandro M Katzin Silvia R B Uliana

The activity of nerolidol, a sesquiterpene used as a food-flavoring agent and currently under testing as a skin penetration enhancer for the transdermal delivery of therapeutic drugs, was evaluated against Leishmania species. Nerolidol inhibited the growth of Leishmania amazonensis, L. braziliensis, and L. chagasi promastigotes and L. amazonensis amastigotes with in vitro 50% inhibitory concent...

Journal: :The Journal of antimicrobial chemotherapy 2008
Krishna Das Manandhar Thakur Prasad Yadav Vijay Kumar Prajapati Subodh Kumar Madhukar Rai Anuradha Dube Onkar Nath Srivastava Shyam Sundar

OBJECTIVES The aim of the present study was to compare the efficacy of a nano form of amphotericin B deoxycholate with that of conventional amphotericin B deoxycholate for the treatment of visceral leishmaniasis. METHODS We have formulated nanoparticles (10-20 nM) from amphotericin B deoxycholate (1-2 microM) by applying high-pressure (150 argon) milling homogenization and have tested their e...

Journal: :Revista Colombiana de Ciencias Químico - Farmacéuticas 2021

Introduction: leishmaniasis is a disease caused by protozoa of the genus Leishmania and considered endemic in 98 countries. Treatment with pentavalent antimonials has high toxicity, which motivates search for effective less toxic drugs. α- β-lapachones have shown different biological activities, including antiprotozoa. In recent studies, isonicotinoylhydrazone phthalazinylhydrazone groups were ...

2017
Lauve Rachel Tchokouaha Yamthe Regina Appiah-Opong Patrick Valere Tsouh Fokou Nole Tsabang Fabrice Fekam Boyom Alexander Kwadwo Nyarko Michael David Wilson

Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the Leishmania genus and transmitted by the female Phlebotomus and Lutzomyia sand flies. The currently prescribed therapies still rely on pentavalent antimonials, pentamidine, paromomycin, liposomal amphotericin B, and miltefosine. However, their low efficacy, long-course treatment regimen, high toxicity...

Journal: :Antimicrobial agents and chemotherapy 1982
J D Berman H K Webster

The possibility that purine inhibitors or analogs might be effective antileishmanial agents led to the determination of the antileishmanial activity of mycophenolic acid and allopurinol in vitro. The drugs were tested against Leishmania tropica amastigotes (mammalian forms) within human macrophages, a model in which achievable serum concentrations of antileishmanial agents currently in use elim...

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