Malatreat is marketed by Paxherbals as a multi-component antimalarial preparation made from Alstonia boonei, Sida acuta and Tridax procumbens. Phytochemical screening of hexane and ethanol extracts obtained by infusion revealed the presence of alkaloids, saponins, tannins, anthraquinones, steroids, flavonoids, phlobatannins, glycosides and cardiac glycosides. These secondary metabolites are als...

The WHO has indicated that in 2009, the most recent year for which data are available, approximately 250 million people were infected with malaria, and nearly one million of those patients succumbed to their infections. But without Youyou Tu (Institute of Materia Medica, Academy of Traditional Chinese Medicine and China Academy of Chinese Medical Sciences) (Figure 1), many of those 249 million ...

Malaria is a major parasitic disease and is responsible for almost one million deaths each year in Africa. There is an urgent need to discover new active compounds. Nature and particularly plants are a potential source of new antimalarial drugs since they contain a quantity of metabolites with a great variety of structures and pharmacological activities. This review covers the compounds with an...

It has been estimated that 300-500 million malaria infections occur on an annual basis and causes fatality to millions of human beings. Most of the drugs used for treatment of malaria have developed drug-resistant parasites or have serious side effects. Plant kingdom has throughout the centuries proved to be efficient source of efficacious malarial drugs like quinine and artemisinin. Since thes...

antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (cq) and amodiaquine (aq), have been used to prevent and treat malaria for many years. the importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. in recent years, with the spread of parasite resistance to cq and cross-resist...

The formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. In this study, we used an improved, cost-effective and high-throughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. Fifteen extracts with different polarity from three Iranian Artemisia species, A. ciniformis, A. biennis an...

The formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. In this study, we used an improved, cost-effective and high-throughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. Fifteen extracts with different polarity from three Iranian Artemisia species, A. ciniformis, A. biennis an...