To study the nephrotoxic effects of occupational exposure to antineoplastic agents, the early renal effect parameters retinol-binding protein (RBP) and albumin (ALB) were determined in the urine of 11 hospital workers involved in the preparation and administration of antineoplastic agents and in 23 hospital workers not involved in drug handling, who served as nonexposed controls. No significant...

OBJECTIVES The increase in oral anticancer medications with complex regimens creates a need to assure that patients are taking therapeutic dosages as prescribed. This article reviews the assessment and measurement of adherence to oral antineoplastic agents. DATA SOURCES Research and journal articles from CINAHL and PubMed. CONCLUSION Assessing and measuring adherence to oral antineoplastics...

Oncology nurses and ancillary support personnel who work in oncology settings are at risk for exposure to antineoplastic drugs in their workplaces. A review of the literature reveals issues of environmental contamination and personal exposure. Although the United States has no formal regulations regarding hazardous drugs, including cytotoxic agents, guidelines have been published and are readil...

The antineoplastic alkaloid camptothecin inhibits nucleic acid synthesis in leukemia LI 210 cells; this inhibition is initially reversible, but becomes irreversible when exposure to the drug is prolonged. A drug-resistant subline, L1210/CN, can overcome camptothecin-induced inhibition of nucleic acid biosynthesis before this becomes irreversible. Unlike actinomycin D-resistant cell lines, L1210...

Garlic has long been used medicinally, most recently for its cardiovascular, antineoplastic, and antimicrobial properties. Sulfur compounds, including allicin, appear to be the active components in the root bulb of the garlic plant. Studies show significant but modest lipid-lowering effects and antiplatelet activity. Significant blood pressure reduction is not consistently noted. There is some ...

BACKGROUND Calcitriol antiproliferative effects include inhibition of the oncogenic ether-à-go-go-1 potassium channel (Eag1) expression, which is necessary for cell cycle progression and tumorigenesis. Astemizole, a new promising antineoplastic drug, targets Eag1 by blocking ion currents. Herein, we characterized the interaction between calcitriol and astemizole as well as their conjoint antipr...

diet can play a vital role in cancer prevention. nowadays the scientists are looking for food materials which can potentially prevent the cancer occurrence. the purpose of this research is to examine anti-mutagenic and apoptotic effects of apigenin in human lymphoma cells. in present study human chronic lymphocytic leukemia (eheb cell line) were cultured in rpmi 1640 (sigma), supplemented with ...

Antineoplastic drug resistance represents a specialized case of drug tolerance since cells most responsive to therapy are destroyed. Clinically, drug resistance may be observed at the onset of therapy or is acquired later by a tumor cell population over time due to a combination of spontaneous genetic mutations and selection by cytotoxic chemotherapy. Numerous mechanisms of drug resistance have...

Pharmacogenomics is the study of the impact of genetic variations or genotypes of individuals on their drug response or drug metabolism. Compared to traditional genomics research, pharmacogenomic research is more closely related to clinical practice. Pharmacogenomic discoveries may effectively assist clinicians and healthcare providers in determining the right drugs and proper dose for each pat...