Recent studies have implicated the complement system in pathogenesis of antineutrophil cytoplasmic antibody-associated vasculitis (AAV), prompting development novel therapeutic agents to target accordingly. The pivotal role component C5a, particular, has been subject a number phase II and III clinical trials. Indeed, US Food Drug Administration already approved avacopan, an oral C5a receptor in...

BACKGROUND Transverse myelitis, subarachnoid hemorrhage, and nephropathy are established but rare complications of hepatitis B virus infection that can potentially be triggered by an antibody-mediated vasculitis as a result of a viral infection. The following is a case report detailing a patient presenting with all three of the above presentations who is cytoplasmic antineutrophil cytoplasmic a...

The coronavirus disease (COVID-19) pandemic has challenged healthcare systems and resulted in complex diagnostic processes for patients with non-COVID-19 pathology. Here, we demonstrate a case of massive alveolar haemorrhage secondary to antineutrophil cytoplasmic antibody-positive vasculitis, presented district general hospital the UK during first wave global pandemic. This highlights some dif...