Materials and methods 1681 HIV positive patients accessing care at Suntreso STI/HIV Clinic in Kumasi, who have been on treatment for more than 12 months and consented to participate were recruited for this cross sectional study. They were interviewed using semi-structured pre-texted questionnaire prior to the commencement of the new fixed dose combination ARVs treatment regime. Data was entered...

Introduction. HIV-1 infection in cell culture is typically characterized by certain cytopathic effects such as vacuolization of cells and development syncytia, which further lead to death. In addition, the majority drugs during HIV treatment exhibit serious adverse patients, apart from their beneficial role. During screening cytoprotective agents protect HIV-1-associated death also drug-associa...

A significant number of human immunodeficiency virus (HIV) infections have become resistant to antiretroviral treatment, which means that there is a paramount need for novel drug targets to defeat the virus. Until recently, all HIV drugs inhibited HIV replication by mechanisms operating inside infected cells. In contrast, new antiretroviral drugs operate outside infected cells. Their mechanism ...

The prevalence of transmitted resistance to antiretroviral drugs varies geographically, with little known about this effect in Asia. In Korea, zidovudine has been widely administered, without charge, through the National AIDS program since the early 1990s; with other potent antiretroviral agents also being introduced in the late 1990s. An analysis of the drug susceptibility to antiretroviral dr...

Methods We report a case of a 47-year-old woman, with diagnosis of HIV infection since 2009 (HLA B5701 negative) that started ARVT in 2011. On the 2nd day of treatment with Tenofovir, Emtricitabine and Nevirapine she developed pruritic exanthema and palpebral edema. Two weeks later the Infecciologist discontinued ARVT and prescribed AH (antihistamines) and CS (oral corticosteroids) with symptom...

There are 28 approved antiretroviral drugs for the treatment of HIV infection; combinations of these drugs clearly change the natural history of HIV, dramatically decreasing HIV-related morbidity and mortality and promoting and prolonging healthy survival. Despite the benefits of HIV treatment, some antiretroviral regimens may be inconvenient, toxic, and/or have suboptimal antiretroviral activi...

objective: the use of antiretroviral drugs has proven remarkably effective in controlling the progression of human immunodeficiency virus (hiv) disease, but these benefits can be compromised by the development of drug resistance. this study aims to assess the drug resistance profile of the pr gene in highly active antiretroviral therapy (haart)-treated and naïve hiv-1 infected patients. metho...

These guidelines are intended as an update to those published in the Southern African Journal of HIV Medicine in 2014 and the update on when to initiate antiretroviral therapy in 2015. Since the release of the previous guidelines, the scale-up of antiretroviral therapy (ART) in southern Africa has continued. New antiretroviral drugs have become available with improved efficacy, safety and robus...