Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. will cause pain and death if not treated properly. OAT (Antituberculosis Drugs) a treatment for tuberculosis patients. has different dosage regimens types of drugs. Treatment TB patients consists two phases (intensive continuation phases). The phase was at to kill dormant bacteria prevent recurrence in purpose this stud...

As a continuation of our research and with the aim of obtaining new antituberculosis agents which can improve the current chemotherapeutic antituberculosis treatments, new series of quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and evaluated for in vitro antituberculosis activity against Mycobacterium tuberculosis strain H(37)Rv, using the radiometric BACTEC 460-TB metho...

We report the case of a 36-year-old man with psoriatic arthritis and miliary tuberculosis, whose serum uric acid (SUA) level increased after the initiation of antituberculosis treatment, which included pyrazinamide. Most strikingly and paradoxically, the patient's SUA level increased after treatment with allopurinol. On cessation of allopurinol, his SUA level decreased substantially, and comple...

STUDY OBJECTIVES To determine whether inactive hepatitis B surface antigen (HBsAg) carriers are at a higher risk of drug-induced hepatotoxicity than control subjects during antituberculosis treatment with standard short-course regimens of isoniazid, rifampin, ethambutol, and/or pyrazinamide. DESIGN Retrospective case-control study. SETTING Tertiary university medical center. PATIENTS One ...

A 24-year old female was admitted with multiple discharging sternal sinuses involving the whole sternum. The cultures grew Mycobacterium tuberculosis. The chest computed tomography (CT) (Figs. 1 and 2) showed the complete destruction of the sternum and paraspinal collection. Triple antituberculosis treatment, surgical drainage of the sternal and spinal abscess and adequate nutrition resulted in...

conclusions according to the presented case and subsequent literature review on fatal ebv hepatitis, clinicians should consider ebv infection in the differential diagnosis when hepatitis occurs in critically ill patients during the anti-tb therapy. although hepatitis caused by ebv is mostly self-limited, some might be fetal. introduction although hepatitis is frequently observed during antitube...

dihydropyridines (dhps) with carboxamides in the 3 and 5 positions show anti-tuberculosis activity. the purpose of the present study was to synthesize new dhps that would possibly possess anti-tuberculosis activity. so a series of n-aryl-1,4-dihydropyridine-3,5-dicarboxamides (3-38) was prepared. they were screened as antitubercular agents against one type of fast growing mycobacterium (m. smeg...