In this study, the activity of the d-opioid receptor subtypeselective agonist, SB 227122, was investigated in a guinea pig model of citric acid-induced cough. Parenteral administration of selective agonists of the d-opioid receptor (SB 227122), m-opioid receptor (codeine and hydrocodone), and k-opioid receptor (BRL 52974) produced dose-related inhibition of citric acid-induced cough with ED50 v...

several therapeutic effects including hypnotic, antispasmodic, treatment of abdominal and chest pain and strengthening the heart have been described for the flowers of rosa damascena. north american indian tribes use a decoction of the roots obtained from the rosa damascena plant as a cough remedy and to treat eye problem. therefore, in the present study the antitussive effect of this plant in ...

203 Undoubtedly, cough is one of the most common symptoms that make people visit physicians for its treatment. It is also apparent that management of chronic cough is not so simple. Underlying causative diseases are diverse, pathogenic mechanism is not clear, and patients' complaints from personal subjective feelings often make physicians even more frustrated. Furthermore , some patients fail t...

BACKGROUND Cough is one of the most common symptoms for which patients seek medical attention from primary care physicians and lung specialists. About 40% of the population at any one time report cough. Cough is associated with significantly impaired health-related quality of life. Levodropropizine is an effective and very well tolerated peripheral antitussive drug. We want to compare it to cen...

Docetaxel (DOX) is one of the clinically used chemotherapeutic agents for treatment breast cancer, instead its severe side effects. Noscapine, an antitussive opium alkaloid, on other hand, has shown antitumor activity against a number cancers without any significant Since both compounds targeted tubulin, it interesting to see combined effect management cancer. The binding energy -3.49 and -4.18...

Anthriscus sylvestris (L.) Hoffm. is a wild herbaceous plant common in most temperate regions. It has been used traditionally to treat headaches, as a tonic, as antitussive, antipyretic, analgesic and diuretic. The plant contains deoxypodophyllotoxin, which is proven to have antitumor and anti-proliferative effects, anti-platelet aggregation, antiviral, anti-inflammatory and insecticidal activi...

BACKGROUND Theophylline has been used in the treatment of asthma and chronic obstructive pulmonary disease for more than 80 years. In addition to bronchodilator and anti-inflammatory activity, clinical studies have suggested that theophylline acts as an antitussive agent. Cough is the most frequent reason for consultation with a family doctor, and treatment options are limited. Determining how ...