The authors review the literature discribing non-dyskinetic antipsychotic withdrawal phenomena. Withdrawal of these agents can cause nausea, emesis, anorexia, diarrhea, rhinorrhea, diaphoresis, myalgia, paresthesia, anxiety, agitation, restlessness, and insomnia. Psychotic relapse is often presaged by increased anxiety, agitation, restlessness and insomnia, but the temporal relationship of thes...

Performance anxiety consists qf several symptoms experienced in the context qf public performance and is classified in DSM-III-R under social phobia. Performance anxiety must be distinguished from panic disorder, generalized social phobia, and generalized anxiety disorder. Petformance anxiety symptoms can be detrimental to both petformer and performance. These symptoms can be controlled by the ...

anxiety is both a normal emotion and a disorder which can cause profound distress and functional impairment. the range of treatments available for anxiety has improved substantially in the last 20 years. this has in part been due to improved understanding of the neurobiological mechanisms underlying anxiety. Guidelines are available for the treatment of the various anxiety disorders; selective ...

The purpose of this longitudinal study (N = 2,745) was to determine whether adolescents' recent medical use of anxiolytic or sleep medication was associated with increased incidence of using someone else's prescription for these classes of medication (nonmedical use). Data were collected from adolescents attending 5 Detroit area secondary schools between December and April in 3 consecutive acad...

Widely used in Europe as a labor analgesic, nitrous oxide (N2O) is making a dramatic return in the United States. Valued for its analgesic properties, N2O also has anxiolytic characteristics. Fear and anxiety in childbirth have been associated with various negative effects, and N2O may have the potential to lessen these effects for some women. Women in the United States should have the option o...

The anxiety-related effects of noscapine were investigated using male Balb-c mice. Since noscapine-induced locomotion may alter the animals' activity level in the dark-light model, the anxiety-related effects of noscapine were studied at doses with no effect on locomotion (0.1, 0.2, 0.3, 0.4, 0.5, 0.8, 1, 1.5 and 2 mg/kg). The parameter measured in dark-light model was the time spent in lit com...

The design and synthesis of the novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole 5 is described. This azepinoindole has excellent affinity for 5-HT(2C) (K(i) 4.8 nM) and modest selectivity over 5-HT(2A) ( approximately 4-fold). Several N- and C(11)-substituted analogues of 5 were prepared, as were a number of biaryl indoline derivatives. The anxiolytic potential for the azepinoindole tem...

BACKGROUND The placebo effect in relieving negative emotion arousal is poorly understood. AIMS We examined whether placebo expectation established with noise stimuli could have a transferable anxiolytic effect on negative emotion arousal. METHODS In Experiment 1, noise intensity was surreptitiously lowered during placebo condition in the preconditioning phase to reinforce placebo expectatio...

Background: A comprehensive approach to pain management often requires multimodal therapy and a combination of medications. Oncology patients may be prescribed methadone duloxetine as single agents or in for cancer-related pain, particularly neuropathic pain. Duloxetine is also depression anxiety with cancer.

Having expanded their original role as primary treatment for depression to preferred treatment for anxiety disorders, antidepressants are now emerging as potential therapeutic agents for many other disorders characterized by distressing or even painful somatic symptoms.