AIMS High-sensitivity cardiac troponin I (cTnI) assays hold promise in detecting the transition from hypertrophy to heart failure in aortic stenosis. We sought to investigate the mechanism for troponin release in patients with aortic stenosis and whether plasma cTnI concentrations are associated with long-term outcome. METHODS AND RESULTS Plasma cTnI concentrations were measured in two patien...

Morphologic analyses of lungs from infants who died of severe aortic stenosis shortly after birth have shown increased pulmonary vascular smooth muscle and an increased number of pulmonary resistance vessels. These findings have been thought to be caused by in utero pulmonary venous, pulmonary arterial or right ventricular hypertension. To study this problem in the fetus, we created aortic sten...

This review examines the treatment options for women with severe aortic stenosis. It is known that female sex is associated with poorer outcomes after surgical aortic valve replacement. With the introduction and adoption of transcatheter aortic valve replacement as an alternative to surgical aortic valve replacement, there are emerging data about the potential impact of female sex-specific char...

Congenital aortic valve anomalies are the cause of premature aortic stenosis in pediatric and younger adult populations. Despite being very rare, unicuspid aortic valves account for approximately 5% of isolated aortic valve replacements. Patients with aortic stenosis, present with the same symptomatology independent of leaflet morphology. However, the presence of bicuspid and unicuspid aortic s...

A total of 14 cases of infective endocarditis (IE) in children aged 6 months to 10 years were seen from December 1987 to December 1992 at the pediatric unit of Ayatollah Taleghani Medical Center. The majority of patients (12 of 14) were between 5 and 10 years of age. Acyanotic congenital heart disease was known to preexist in 78.6% and rheumatic valvular heart disease in 21.4% of cases. Or...

Aortic valve stenosis resulting from calcific thickening of a previously normal 3-cusp aortic valve or a congenitally bicuspid aortic valve is a common clinical condition in developed countries, and its prevalence is continuing to increase with aging of the population.1,2 In the Cardiovascular Health Study, which involved 5201 men and women 65 years of age, the prevalence of aortic stenosis was...

In a prospective study made between 1 September 1996 and 31 December 2001, pediatric patients with a diagnosis of supravalvular aortic stenosis confirmed by a reduction in the aortic inner diameter and a gradient > or = 50 mmHg were detected. Of 83 patients with aortic stenosis, only 7 (8.4%) had supravalvular aortic stenosis. All 7 patients underwent surgical treatment consisting of resection ...

Morphologic analyses of lungs from infants who died of severe aortic stenosis shortly after birth have shown increased pulmonary vascular smooth muscle and an increased number of pulmonary resistance vessels. These findings have been thought to be caused by in utero pulmonary venous, pulmonary arterial or right ventricular hypertension. To study this problem in the fetus, we created aortic sten...

transcatheter aortic valve replacement (tavr) is a novel therapeutic intervention for the replacement of severely stenotic aortic valves in high-risk patients for standard surgical procedures. since the initial partner trial results, use of tavr has been on the rise each year. new delivery methods and different valves have been developed and modified in order to promote the minimally invasive p...

BACKGROUND Dilatation of the ascending aorta in aortic stenosis may be partly explained by intrinsic wall structure changes, but the relative contribution of altered hemodynamics is unclear. The aim of this study was to assess the association between ascending aortic dimensions and valve stenosis severity. METHODS AND RESULTS An analysis of echocardiographic examinations was conducted in 296 ...