Rhoptries are connected to an apical vesicle which is docked the plasma membrane (PM) and extends a rosette of PM-embedded intramembranous particles via electron-dense connecting material. Rhoptry secretion thus involves multiple membrane-fusion events. The essential for rhoptry but dispensable microneme exocytosis. Rosette formation exocytosis require conserved proteins that restricted Alveola...

The genus Cyclospora is in the subclass Coccidia, phylum Apicomplexa. This genus is taxonomically related to coccidian genera in humans. This organism has previously been referred to as a cyanobacterium-like body (CLB) and, in recent years, a new coccidian pathogen, Cyclospora cayetanensis, has been putatively identified (1, 2). No other species of Cyclospora affecting humans have yet been dete...

introduction babesiosis is caused by apicomplexa parasites of the genus babesia. humans are commonly infected by babesia through tick bites. there is limited information available about babesia infection of humans in china. the aim of this study was to isolate the pathogen from a patient with severe parasitemia. case presentation blood samples were observed by transmission electron microscopy (...

The cytoskeleton plays a fundamental role in various processes such as the establishment of cell shape, cell locomotion, and the intracellular motility of various structures found in eukaryotic cells. Microtubules are among the most conspicuous structures in the cytoskeleton. They can be found free in the cytoplasm, forming the mitotic spindle or assembled in various structures. A special type ...

Neospora caninum, of the Apicomplexa phylum, is a common cause of abortions in cattle and nervous system dysfunction in dogs. Rhoptry proteins of Apicomplexa play an important role in virulence. The objectives of this study were to study functions of NcROP5 in N. caninum by deleting the NcROP5 gene from the wild Nc-1 strain. We selected NcROP5 in ToxoDB and successfully constructed an NcROP5 ge...

Malaria is caused by species in the apicomplexan genus Plasmodium, which infect hundreds of millions of people each year and kill close to one million. While malaria is the most notorious of the apicomplexan-caused diseases, other members of eukaryotic phylum Apicomplexa are responsible for additional, albeit less well-known, diseases in humans, economically important livestock, and a variety o...