نتایج جستجو برای: apj
تعداد نتایج: 745 فیلتر نتایج به سال:
Endocannabinoids behave as antifibrogenic agents by interacting with cannabinoid CB2 receptors, whereas the apelin (AP) system acts as a proangiogenic and profibrogenic mediator in the liver. This study assessed the effect of long-term stimulation of CB2 receptors or AP receptor (APJ) blockade on fibrosis progression in rats under a non-discontinued fibrosis induction program. The study was per...
Apelin, an endogenous ligand for APJ receptor, has been reported to be upregulated in paraventricular nucleus (PVN) following stress. Central apelin is known to stimulate release of corticotropin-releasing factor (CRF) via APJ receptor. We tested the hypothesis that stress-induced gastrointestinal (GI) dysfunction is mediated by central apelin. We also assessed the effect of exogenous apelin on...
BACKGROUND Apelin is among the most potent stimulators of cardiac contractility known. However, no physiological or pathological role for apelin-angiotensin receptor-like 1 (APJ) signaling has ever been described. METHODS AND RESULTS We performed transcriptional profiling using a spotted cDNA microarray with 12 814 unique clones on paired samples of left ventricle obtained before and after pl...
Apelin has been identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ. This peptide exerts a variety of cardiovascular effects and particularly acts as an activator of angiogenesis. Importantly, hypoxia has been reported to regulate apelin expression but the molecular mechanism underlying hypoxia-induced apelin expression and the relationship with the physiologi...
Whereas the role of the G-protein-coupled APJ receptor and its ligand, apelin, in angiogenesis has been well documented, the ability of the apelin/APJ system to induce lymphangiogenesis and lymphatic metastasis has been largely unexplored. To this end, we first show that APJ is expressed in lymphatic endothelial cells (LECs) and, moreover, that it responds to apelin by activating the apelinergi...
A gene encoding a novel class a G-protein-coupled receptor was discovered in 1993 by homology cloning and was called APJ. It was designated an "orphan" receptor until 1998, when its endogenous ligand was identified and named apelin (for APJ endogenous ligand). Since this pairing, both apelin and its receptor have been found to have a widespread distribution in both the central nervous system an...
Recently Titov et al [ApJ 693,(2009) and ApJ (2007)] have made use of a covariant model to investigate magnetic reconnection of astrophysical plasmas. Earlier R Ricca [Phys Rev A (1991)] has used another covariant formalism, to investigated vortex filaments and solitons. This formalism, called Ricci rotation coefficients (RRC), is applied here, to the Chui and Moffatt [PRSA (1995)] knotted magn...
Context. A specific example of Bianchi type VIIh models, i.e. those including universal rotation (vorticity) and differential expansion (shear), has been shown in Jaffe et al. (2005, ApJ, 629, L1) to correlate unexpectedly with the WMAP first-year data. Aims. We re-assess the signature of this model in the WMAP 3-year data. Methods. The cross-correlation methods are described in Jaffe et al. (2...
The G protein-coupled receptor (GPCR) dimer interface plays an important role in the formation and stabilization of dimer. Therefore, identifying potential receptor-receptor is part studying GPCRs. Various strategies have been employed to study GPCR explore its functional significance, but experimental methods lack robustness calculations are laborious. Herein, we report a combined optimized ca...
Apelin is a regulatory peptide, identified as an endogenous ligand of the Apelin receptor (APJ). Both the apelin and the APJ were detected in brain, lung, heart, mammary gland, kidney, placenta, adipose tissues and the gastrointestinal tract. Apelin is considered an important regulatory gut peptide with a potential physiological role in gastrointestinal cytoprotection, regulation of food intake...
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