measles virus (mv) is a highly contagious agent which causes a major health problem in developing countries. we studied the effect of buthionine sulfoximine (bso) on the replication of an aik-hdc strain of mv and its induced apoptosis in vero cell lines. methods: in this study, toxicity of bso on vero cells was investigated first, resulted in determination of sub-lethal or non-toxic concentrati...

objective(s): oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. licochalcone b, an extract of licorice root, has shown antioxidative properties. this study was to investigate the effects and mechanisms of licochalcone b in ethanol-induced hepatic injury in an in vitro study. materials and methods: an in vitro model of ethanol-induced cytotoxicity in brl cel...

objective: gastric cancer is a major health issue worldwide. using a therapeutic approach, with minor side-effects, is very essential for the treatment of the gastric cancer. shiraia bambusicola is a parasitic fungus which is widely used in china for curing several diseases with little side-effects. however, the mechanisms are not well understood yet. the aim of this study was to further unders...

Background/Aim: This study was designed to investigate the effect of IL-39 on T24 bladder cancer (BC) cell line survival and growth. Materials Methods: In order assess direct survival, proliferation, apoptosis BC cells, we utilized a clonogenic assay, proliferation caspase-3 activity kits. Potential proliferative apoptotic molecular mechanisms were evaluated by RT-PCR. Results: Treatment cells ...

Metastasis to lymph nodes and distant organs is the main challenge in the treatment of papillary thyroid cancer. In the current investigation, we aimed to evaluate the synergistic effects of celecoxib (CX) and sodium valproate (VPA) against cell survival, invasiveness properties, and expression of metalloproteinase-2 and -9 (MMP-2 and MMP-9) in  papillary thyroid cancer cell line, BCPAP cells. ...

Metastasis to lymph nodes and distant organs is the main challenge in the treatment of papillary thyroid cancer. In the current investigation, we aimed to evaluate the synergistic effects of celecoxib (CX) and sodium valproate (VPA) against cell survival, invasiveness properties, and expression of metalloproteinase-2 and -9 (MMP-2 and MMP-9) in  papillary thyroid cancer cell line, BCPAP cells. ...

Background: Radiotherapy is an established therapeutic modality for prostate cancer. Resveratrol, a natural antioxidant, has been shown to inhibit carcinogenesis and to block the process of tumor initiation and progression. No data is available on the response of cellular spheroid to Reseveratol. In this study we have examined the effect of Resveratol on the radiation response of human p...

Background As a fatal disease, the mechanism of pancreatic cancer is unclear. Urothelial carcinoma antigen 1(UCA1), long noncoding RNA (lncRNA) that was first reported in bladder cancer, acts as an oncogene. However, regulatory role and UCA1 remain unknown. This study aims to investigate expression level prognostic value tissues, effects regulating cell proliferation, apoptosis metastasis. Meth...

Interferon regulatory factor 2 (IRF2) participates in the differentiation of immune T cells. Bone marrow mesenchymal stem cell (BM-MSC)-derived exosomes can secret mRNA, miRNAs, and proteins to regulate tumor microenvironment. The present study focused on miRNA/IRF2 axis regulating Th1/Th2 ratio apoptosis acute myeloid leukemia (AML). flow cytometry analysis was performed examine AML vivo vitro...

Purpose: To investigate the effect of micro-ribonucleic acid (miR)-208a on heart failure (HF) in rats through β-catenin pathway.Methods: A total 24 specific pathogen-free female Sprague-Dawley were enrolled and randomly divided into 3 equal groups, namely, control (normal group), model, study group (miR-208a), with 8 each. Echocardiography was utilized to evaluate cardiac function, terminal deo...