UNLABELLED Enteropathogenic Escherichia coli (EPEC) has the ability to antagonize host apoptosis during infection through promotion and inhibition of effectors injected by the type III secretion system (T3SS), but the total number of these effectors and the overall functional relationships between these effectors during infection are poorly understood. EspC produced by EPEC cleaves fodrin, paxi...

Caspase-8 is the main initiator caspase in death receptor-induced apoptosis. Procaspase-8 is activated at the death-inducing signaling complex (DISC). Previous studies suggested a two-step model of procaspase-8 activation. The first cleavage step occurs between the protease domains p18 and p10. The second cleavage step takes place between the prodomain and the large protease subunit (p18). Subs...

Caspase-2, one of the earliest discovered caspases, has emerged as a multifunctional enzyme with roles that are not limited to cell death. It acts as a tumor suppressor, prevents genetic instability, and protects against aging by playing a crucial role in sensing alterations in cellular redox status and activating the antioxidant defense system. These apparent non-apoptotic functions, only disc...