FE65 binds to the Alzheimer amyloid precursor protein (APP), but the function of this interaction has not been identified. Here, we report that APP and FE65 are involved in regulation of cell movement. APP and FE65 colocalize with actin and Mena, an Abl-associated signaling protein thought to regulate actin dynamics, in lamellipodia. APP and FE65 specifically concentrate with beta 1-integrin in...

we give a survey of recent applications of group rings to combinatorics and tocryptography, including their use in the di erential cryptanalysis of block ciphers.

This paper aims to provoke innovative iPhone app ideas while discouraging those that are already flooding the Apple App Store. It also discusses methods for generating revenue and gaining app publicity. By taking a close look at the iPhone’s capabilities, and examining already-successful apps, we see how an app can be unique, intriguing, popular, or just downright useful. Furthermore, through m...

The transport of Balbiani ring (BR) premessenger RNP particles in the larval salivary gland cells of the dipteran Chironomus tentans can be followed using electron microscopy. A BR RNP particle consists of an RNP ribbon bent into a ringlike structure. Upon translocation through the nuclear pore complex (NPC), the ribbon is straightened and enters the central channel of the NPC with the 5' end o...

An efficient N-heterocyclic carbene (NHC) catalyzed sulfenylation reaction of α,β-unsaturated aldehydes with N-(arylthio)phthalimide has been developed. A wide variety of α-thioenals can be obtained with good to excellent yields and excellent Z-configuration.

In this paper we construct a q-deformation of the Witt-Burnside ring of a profinite group over a commutative ring, where q ranges over the ring of integers. When q = 1, this coincides with the Witt-Burnside ring introduced by A. To achieve our goal we show that there exists a q-deformation of the necklace ring of a profinite group over a commutative ring. As in the classical case, i.e., the cas...

The following result is proved: Let R be a 2-torsion free semiprime ring, and let T : R → R be an additive mapping, related to a surjective homomorphism θ : R → R, such that 2T (x2) = T (x)θ(x) + θ(x)T (x) for all x ∈ R. Then T is both a left and a right θ-centralizer.

Increased generation of amyloid peptide (A ) derived from amyloid precursor protein (APP) is the primary pathological characteristic of Alzheimer’s disease (AD). However, the sub cellular compartment in which APP undergoes cleavage by secretases to generate A is not precisely known. Compelling evidences suggest that amyloidogenic processing of APP occurs in lipid rafts. An indirect support for ...

A critical role of the amyloid precursor protein (APP) in Alzheimer's disease (AD) pathogenesis has been well established. However, the physiological function of APP remains elusive and much debated. We reported previously that the APP family of proteins is essential in mediating the developing neuromuscular synapse. In the current study, we created a conditional allele of APP and deleted APP i...

Amyloid-beta peptide, which accumulates in senile plaques in Alzheimer's disease, is derived from the amyloid precursor protein (APP) by proteolytic processing. beta-secretase (Asp2), which cleaves APP at the N-terminus of amyloid-beta, has recently been identified to be the protease BACE. In the present study, we examined the subcellular localization of interactions between APP and BACE by usi...