The serum amyloid A (SAA) protein is known to function in the acute phase response and immunoregulation. Recently, SAA has been shown to be involved in cell proliferation, differentiation and migratory behavior in different cell types. Here, we evaluated whether exogenous SAA could influence trophoblast invasion and differentiation using both the trophoblast-like BeWo cell line and fully differ...

Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited extracellularly as insoluble amyloid fibrils that damage tissue structure and function. Clinical AA amyloidosis is typically preceded by many years of active inflammation before presenting, most commonly with renal involvement. Using dose-dep...

OBJECTIVES Salivary alpha-amylase (sAA) has been utilized as a non-invasive measure of sympathoadrenal medullary (SAM) activation. Little is known regarding the relationship between personality inventories and baseline sAA. This study was designed to examine the relationships between the scores of big five inventory (BFI) factors, age, and sAA in adults (aged twenty to seventy years old). MET...

This article proposes a method for identifying potential self-adequate sub-networks in the existing power distribution grid. These can be equipped with control and protection schemes to form microgrids capable of sustaining local loads during systems contingencies, thereby mitigating disasters. Towards best microgrid candidates, this work formulates chance-constrained optimal network partitioni...

The complex of serum amyloid A(SAA) and low-density lipoprotein (LDL), SAA-LDL, is considered a new and unique marker of oxidatively-modified LDL particles, which is associated with atherosclerotic conditions. This study investigated the influence of atorvastatin treatment on circulating SAA-LDL levels among asymptomatic hypercholesterolemic patients. A total of 26 patients (mean age 63 years) ...

BACKGROUND Atherosclerosis is a chronic inflammatory disorder, and several studies have demonstrated a positive association between plasma serum amyloid A (SAA) levels and cardiovascular disease risk. The aim of the study was to examine whether SAA has a role in atherogenesis, the underlying basis of most cardiovascular disease. METHODS AND RESULTS Mice globally deficient in acute-phase isofo...

Background-—Atherosclerosis is a chronic inflammatory disorder, and several studies have demonstrated a positive association between plasma serum amyloid A (SAA) levels and cardiovascular disease risk. The aim of the study was to examine whether SAA has a role in atherogenesis, the underlying basis of most cardiovascular disease. Methods and Results-—Mice globally deficient in acute-phase isofo...

Conditional Value at Risk (CVaR) has been recently used to approximate a chance constraint. In this paper, we study the convergence of stationary points when sample average approximation (SAA) method is applied to a CVaR approximated joint chance constrained stochastic minimization problem. Specifically, we prove, under some moderate conditions, that optimal solutions and stationary points obta...

In this work we present explicit definitions for the sample complexity associated with the Sample Average Approximation (SAA) Method for instances and classes of multistage stochastic optimization problems. For such, we follow the same notion firstly considered in Kleywegt et al. (2001). We define the complexity for an arbitrary class of problems by considering its worst case behavior, as it is...

The sample average approximation (SAA) method is an approach for solving stochastic optimization problems by using Monte Carlo simulation. In this technique the expected objective function of the stochastic problem is approximated by a sample average estimate derived from a random sample. The resulting sample average approximating problem is then solved by deterministic optimization techniques....